Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.400 Biomarker PSYGENET The results showed that the COMT polymorphism influenced the volume of the bilateral ventral caudate nucleus in both groups, but in an opposite direction: more copies of val allele led to lesser volume in chronic cannabis users and more volume in controls. 23311613

2014

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.400 Biomarker PSYGENET Adolescents with the Met/Met genotype and high rates of MB-COMT promoter methylation were less likely to be high-frequent cannabis users than adolescents with the Val/Val or Val/Met genotype. 24902721

2014

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.400 Biomarker PSYGENET Cannabis users carrying the COMT val/val genotype exhibited lower accuracy of sustained attention, associated with a more strict response bias, than val/val non-users. 23449176

2013

Entrez Id: 2166
Gene Symbol: FAAH
FAAH
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.380 Biomarker PSYGENET These findings support an association with CNR1 and FAAH genes and marijuana-related problems among regular marijuana users. 24172113

2013

Entrez Id: 2166
Gene Symbol: FAAH
FAAH
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.380 Biomarker PSYGENET These findings suggest that, in the absence of FAAH, AEA produces intoxication comparable to THC, and consequently to marijuana. 21300050

2011

Entrez Id: 2166
Gene Symbol: FAAH
FAAH
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.380 Biomarker PSYGENET These findings are in accord with earlier reported associations between CNR1 and FAAH and CD intermediate phenotypes, and suggest that the underlying mechanism of these genetic effects may be enhanced neural response in reward areas of the brain in carriers of the CNR1 G allele and FAAH C/C genotype in response to marijuana cues. 20010552

2010

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.370 Biomarker PSYGENET Growing evidence indicated conflicting results about the dopamine receptor D2 (DRD2)/kinase domain containing 1 gene (ANKK1) TaqIA single nucleotide polymorphism (rs1800497) and common illicit drug dependence risk including stimulants, opioid and marijuana. 25500252

2015

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.370 Biomarker PSYGENET Dopamine receptor D2 (DRD2) and proenkephalin (PENK) genes have been implicated in animal studies with cannabis exposure. 22745721

2012

Entrez Id: 1269
Gene Symbol: CNR2
CNR2
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.330 Biomarker PSYGENET In conclusion, marijuana users that had smoked marijuana ≥20 times in their lives and stopped cannabis use at least 6 months before the study show an increase in CB2 receptor mRNA in the blood and in serum anandamide level. 24788457

2014

Entrez Id: 1815
Gene Symbol: DRD4
DRD4
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.330 Biomarker PSYGENET Overall, the results suggested that the DRD4 polymorphism may be relevant to differences in the developmental trajectories of marijuana use. 23790981

2013

Entrez Id: 1815
Gene Symbol: DRD4
DRD4
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.330 Biomarker PSYGENET To investigate the combined effect of an exon III variable number tandem repeat in the dopamine receptor gene (DRD4) and insecure attachment style on risk for tobacco, cannabis and alcohol use problems in young adulthood. 22126256

2013

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.330 Biomarker PSYGENET Finally, cannabis users carrying the 5-HTTLPR s/s genotype had worse IGT performance than s/s non-users. 23449176

2013

Entrez Id: 1815
Gene Symbol: DRD4
DRD4
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.330 Biomarker PSYGENET This study examined associations between the DRD4 gene 48bp VNTR polymorphism and comorbidity between marijuana use frequency and depression in a diverse, non-clinical adolescent sample (n=1882; ages 14 to 18) from the National Longitudinal Study of Adolescent Health (Add Health). 23796967

2013

Entrez Id: 1815
Gene Symbol: DRD4
DRD4
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.330 Biomarker PSYGENET This study shows that carriers of the DRD4 7-repeat allele are disproportionally affected by the negative and positive effects of parental monitoring such that carriers of the DRD4 7-repeat allele, as compared to non-carriers, are more likely to use cannabis when levels of parental monitoring are low, and less likely to use cannabis when parental monitoring levels are high. 23209577

2012

Entrez Id: 5179
Gene Symbol: PENK
PENK
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.330 Biomarker PSYGENET Cigarette smoking is common in cannabis users, but it was not associated to PENK SNPs as also validated in another cohort (N = 247 smokers, N = 312 non-smokers). 22745721

2012

Entrez Id: 5179
Gene Symbol: PENK
PENK
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.330 Biomarker PSYGENET Proenkephalin mediates the enduring effects of adolescent cannabis exposure associated with adult opiate vulnerability. 22683090

2012

Entrez Id: 5179
Gene Symbol: PENK
PENK
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.330 Biomarker PSYGENET Prenatal cannabis exposure was significantly associated with increased mu receptor expression in the amygdala, reduced kappa receptor mRNA in mediodorsal thalamic nucleus and reduced preproenkephalin expression in the caudal putamen. 16477274

2006

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.320 Biomarker PSYGENET Here, we found that in mice, subchronic administration of the psychoactive component of cannabis, delta9-tetrahydrocannabinol (THC), activated cerebellar microglia and increased the expression of neuroinflammatory markers, including IL-1β. 23934130

2013

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.310 Biomarker PSYGENET Statistical analyses indicated that overexpression of the EGFR cascade is significantly correlated to cannabis smoking. 25736926

2015

Entrez Id: 51083
Gene Symbol: GAL
GAL
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.310 Biomarker PSYGENET Initial findings showed a positive relationship of cannabis usage (OR = 2.070, P = 0.007, N = 406 (individuals who had used cannabis at least once within the last 12 months, total sample size 2731) with the GG haplotype, consistent with the previous published data linking galanin with an increased release of dopamine. 25228436

2014

Entrez Id: 1432
Gene Symbol: MAPK14
MAPK14
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.310 Biomarker PSYGENET Of the MAPK14 tSNPs, only rs12199654 had significant genotype effects and genotype × marijuana misuse interaction effects on WM volumes. rs12199654-A homozygotes with marijuana abuse/dependence had significantly smaller total cerebral and lobar WM volumes. 22850347

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.310 Biomarker PSYGENET Because p53, a tumor suppressor gene, has an important pathophysiologic role in the regulation of lung epithelial cell DNA damage responses, we hypothesized that p53 may be involved in the oxidative stress-mediated apoptosis induced by marijuana smoking. 23665932

2013

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.310 Biomarker PSYGENET These results suggest that the applicability of medical marijuana would be broadened by concurrent inhibition of COX-2. 24267894

2013

Entrez Id: 26575
Gene Symbol: RGS17
RGS17
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.310 Biomarker PSYGENET The G allele of SNP rs596359, in the RGS17 promoter region, was associated with AD, CD, OD, or MjD in both populations (0.005≤P(empirical)≤0.019). 22591552

2012

Entrez Id: 3060
Gene Symbol: HCRT
HCRT
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse
0.310 Biomarker PSYGENET Orexin A gene expression was statistically significantly correlated with the Satisfaction with Life Scale (r = -0.28, p = 0.018), a visual analogue scale of craving (r = 0.734, p = 0.000) and three subscales of the World Health Organization Alcohol, Smoking and Substance Involvement Screening Test, i.e. nicotine consumption (r = 0.388, p = 0.001), alcohol consumption (r = 0.354, p = 0.002) and cannabis consumption (r = 0.783, p = 0.000). 22846875

2012