Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Results showed reduced endothelial nitric oxide synthase (eNOS) protein expression in the MI group; increased iNOS activity in the HgCl<sub>2</sub>-MI group, although without enough magnitude to reverse the reduction in NO bioavailability; and increased phenylephrine response in the HgCl<sub>2</sub>-MI group due to an increase in ROS production, notably via xanthine oxidase (XO). 28980197

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Simvastatin ameliorates ventricular remodeling via the TGF‑β1 signaling pathway in rats following myocardial infarction. 27121011

2016

Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Therapeutic RGD Ad-HGF improves the cardiac remodeling of rat following myocardial infarction by upregulating autophagy and necroptosis and inhibiting apoptosis. 27904666

2016

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Evaluation of the anti-myocardial ischemia effect of individual and combined extracts of Panax notoginseng and Carthamus tinctorius in rats. 23237935

2013

Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Therapeutic RGD HMGB1 injection with Dex-PCL-HEMA/PNIPAAm hydrogel attenuates cardiac remodeling and improves cardiac function after MI by inducing myocardial regeneration. 23188125

2013

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Delayed anesthetic preconditioning protects against myocardial infarction via activation of nuclear factor-κB and upregulation of autophagy. 23143013

2013

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Therapeutic RGD MI also significantly increased ACE and angiotensin type 1 receptor levels but decreased ACE2 activity by 40% (control, 246.2±25.1; DIZE alone, 254.2±20.6; MI, 148.9±29.2; RFU/min), which was reversed by DIZE treatment. 23959549

2013

Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Impairment of cardiac function and remodeling induced by myocardial infarction in rats are attenuated by the nonpeptide angiotensin-(1-7) analog AVE 0991. 21167013

2012

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD The results showed that post-MI exposure of rats to daily cycles of hyperoxygenation (oxygen cycling) improved stem cell engraftment, cardiac function, and increased NOS3 expression. 22012955

2012

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Tumour necrosis factor-α and its receptors in the beneficial effects of vagal stimulation after myocardial infarction in rats. 21362018

2011

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Effects of captopril and angiotensin II receptor blockers (AT1, AT2) on myocardial ischemia-reperfusion induced infarct size. 21975128

2011

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Bone marrow mesenchymal stem cell transplantation combined with perindopril treatment attenuates infarction remodelling in a rat model of acute myocardial infarction. 16845718

2006

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Therapeutic RGD By day 28, increases in ACE (P = 0.005) and ACE2 (P = 0.006) mRNA were also seen in the viable myocardium of MI rats compared with myocardium of control rats. 15671045

2005

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD ET(A)-receptor blockade prevents matrix metalloproteinase activation late postmyocardial infarction in the rat. 11179039

2001

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat. 10773235

2000

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Regulation of collagen degradation in the rat myocardium after infarction. 8531210

1995

Entrez Id: 4878
Gene Symbol: NPPA
NPPA
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.570 Biomarker RGD SERCA2a gene down-regulation in the non-infarcted myocardium of rats with MI does not correlate with ANP gene up-regulation, suggesting that the two genes are not antithetically regulated. 16087130

2005

Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.560 Therapeutic RGD Rosuvastatin changes cytokine expressions in ischemic territory and preserves heart function after acute myocardial infarction in rats. 23139358

2013

Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.560 Therapeutic RGD Erythropoietin affords additional cardioprotection to preconditioned hearts by enhanced phosphorylation of glycogen synthase kinase-3 beta. 16565311

2006

Entrez Id: 2626
Gene Symbol: GATA4
GATA4
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.550 Therapeutic RGD Phenanthrene exposure causes cardiac arrhythmia in embryonic zebrafish via perturbing calcium handling. 23948075

2013

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.540 Biomarker RGD Herein, we reported that the relative protein levels of RIP140/PGC-1α were up-regulated in the failing hearts after chronic myocardial infarction (MI), and correlated negatively with the energy state index phosphocreatine (PCr)/ATP ratios. 22503866

2012

Entrez Id: 847
Gene Symbol: CAT
CAT
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.540 Biomarker RGD Antioxidant enzyme gene expression in congestive heart failure following myocardial infarction. 14575298

2003

Entrez Id: 6285
Gene Symbol: S100B
S100B
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.530 Biomarker RGD These results suggest that interaction of RAGE and its ligand S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53 signaling. 19910580

2010

Entrez Id: 8678
Gene Symbol: BECN1
BECN1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.520 Therapeutic RGD Myocardial autophagy variation during acute myocardial infarction in rats: the effects of carvedilol. 20079142

2009

Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.520 Biomarker RGD Antioxidant enzyme gene expression in congestive heart failure following myocardial infarction. 14575298

2003