Source: MGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.220 Biomarker MGD A hearing and vestibular phenotyping pipeline to identify mouse mutants with hearing impairment. 20057387

2010

Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.220 Biomarker MGD A mutation in the F-box gene, Fbxo11, causes otitis media in the Jeff mouse. 17035249

2006

Entrez Id: 51297
Gene Symbol: BPIFA1
BPIFA1
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.210 Biomarker MGD From these observations, we conclude that loss of Splunc1 predisposes mice to the development of otitis media. 25765466

2015

Entrez Id: 7050
Gene Symbol: TGIF1
TGIF1
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.210 Biomarker MGD Otitis media in the Tgif knockout mouse implicates TGFβ signalling in chronic middle ear inflammatory disease. 23459932

2013

Entrez Id: 51297
Gene Symbol: BPIFA1
BPIFA1
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.210 Biomarker MGD SPLUNC1/BPIFA1 contributes to pulmonary host defense against Klebsiella pneumoniae respiratory infection. 23499554

2013

Entrez Id: 285590
Gene Symbol: SH3PXD2B
SH3PXD2B
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.210 Biomarker MGD Anterior segment dysgenesis and early-onset glaucoma in nee mice with mutation of Sh3pxd2b. 21282566

2011

Entrez Id: 6169
Gene Symbol: RPL38
RPL38
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.210 Biomarker MGD Together, these data present a previously uncharacterized combination of interrelated middle ear pathologies and suggest Rpl38 deficiency as a model to dissect the causative relationships between neo-ossification, cholesterol crystal deposition, and Eustachian tubes in the etiology of otitis media. 21062742

2011

Entrez Id: 285590
Gene Symbol: SH3PXD2B
SH3PXD2B
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.210 Biomarker MGD The podosomal-adaptor protein SH3PXD2B is essential for normal postnatal development. 19669234

2009

Entrez Id: 6169
Gene Symbol: RPL38
RPL38
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.210 Biomarker MGD Fetal erythropoiesis and hemoglobin ontogeny in tail-short (Ts/+) mutant mice. 465735

1979

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.200 Biomarker MGD Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase. 28592560

2017

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.200 Biomarker MGD Here, we report on otitis media-related hearing loss in asj (ages with stiffened joints) mutant mice, which bear a point mutation in the Enpp1 gene. 27959908

2016

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.200 Biomarker MGD Spontaneous asj-2J mutant mouse as a model for generalized arterial calcification of infancy: a large deletion/insertion mutation in the Enpp1 gene. 25479107

2014

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.200 Biomarker MGD Mutant Enpp1asj mice as a model for generalized arterial calcification of infancy. 23798568

2013

Entrez Id: 4000
Gene Symbol: LMNA
LMNA
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.200 Biomarker MGD Pathological features in the LmnaDhe/+ mutant mouse provide a novel model of human otitis media and laminopathies. 22819531

2012

Entrez Id: 4000
Gene Symbol: LMNA
LMNA
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.200 Biomarker MGD Mitotic defects lead to pervasive aneuploidy and accompany loss of RB1 activity in mouse LmnaDhe dermal fibroblasts. 21464947

2011

Entrez Id: 7161
Gene Symbol: TP73
TP73
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.200 Biomarker MGD microRNA-34a regulates neurite outgrowth, spinal morphology, and function. 22160706

2011

Entrez Id: 25776
Gene Symbol: CBY1
CBY1
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.200 Biomarker MGD Altered lung morphogenesis, epithelial cell differentiation and mechanics in mice deficient in the Wnt/β-catenin antagonist Chibby. 21049041

2010

Entrez Id: 2122
Gene Symbol: MECOM
MECOM
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.200 Biomarker MGD A hearing and vestibular phenotyping pipeline to identify mouse mutants with hearing impairment. 20057387

2010

Entrez Id: 4000
Gene Symbol: LMNA
LMNA
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.200 Biomarker MGD Disheveled hair and ear (Dhe), a spontaneous mouse Lmna mutation modeling human laminopathies. 20376364

2010

Entrez Id: 25776
Gene Symbol: CBY1
CBY1
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.200 Biomarker MGD Inactivation of Chibby affects function of motile airway cilia. 19364920

2009

Entrez Id: 5251
Gene Symbol: PHEX
PHEX
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.200 Biomarker MGD A mouse model with postnatal endolymphatic hydrops and hearing loss. 18289812

2008

Entrez Id: 2070
Gene Symbol: EYA4
EYA4
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.200 Biomarker MGD We suggest that some human otitis media susceptibility reflects underlying genetic predisposition in genes like EYA4 that regulate middle ear and eustachian tube anatomy. 18219393

2008

Entrez Id: 57167
Gene Symbol: SALL4
SALL4
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.200 Biomarker MGD A Sall4 mutant mouse model useful for studying the role of Sall4 in early embryonic development and organogenesis. 17216607

2007

Entrez Id: 3425
Gene Symbol: IDUA
IDUA
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.200 Biomarker MGD Age-related functional and histopathological changes of the ear in the MPS I mouse. 17101178

2007

Entrez Id: 4669
Gene Symbol: NAGLU
NAGLU
CUI: C0029882
Disease: Otitis Media
Otitis Media
0.200 Biomarker MGD Development of sensory, motor and behavioral deficits in the murine model of Sanfilippo syndrome type B. 17712420

2007