Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker CTD_human We measured AKT1 and GSK-3β proteins and phosphorylation in human peripheral blood mononuclear cells, functional MRI cingulate response during attentional control, behavioral accuracy during sustained attention, and response to 8 wk of treatment with olanzapine in a total of 190 healthy subjects and 66 patients with schizophrenia. 21187413

2011

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker CTD_human Our study suggests that AKT1 is a susceptibility gene for schizophrenia in the Chinese population and that the AKT1 gene may play no major role in the therapeutic response to antipsychotics or in chlorpromazine-induced extrapyramidal syndrome. 17915974

2007

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker CTD_human For schizophrenia, positive associations of SNPs and AKT1 haplotypes were reported in US and Japanese samples. 15982448

2006

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker CTD_human Consistent with this proposal, we also show that haloperidol induces a stepwise increase in regulatory phosphorylation of AKT1 in the brains of treated mice that could compensate for an impaired function of this signaling pathway in schizophrenia. 14745448

2004

Entrez Id: 9863
Gene Symbol: MAGI2
MAGI2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.850 Biomarker CTD_human One of the rare CNVs found in SZ cohorts is the duplication of Synaptic Scaffolding Molecule (S-SCAM, also called MAGI-2), which encodes a postsynaptic scaffolding protein controlling synaptic AMPA receptor levels, and thus the strength of excitatory synaptic transmission. 25653350

2015

Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker CTD_human Our findings link NRXN2 disruption to the pathogenesis of ASD for the first time and further strengthen the involvement of NRXN1 in SCZ, supporting the notion of a common genetic mechanism in these disorders. 21424692

2011

Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker CTD_human At a gene level, CAM genes associated in all three samples (NRXN1 and CNTNAP2), which were previously implicated in specific language disorder, autism and schizophrenia. 20157312

2011

Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker CTD_human The data strongly confirm the association of schizophrenia with 1q21.1, 15q13.3, and 22q11.21 deletions, 16p11.2 duplications, and exonic NRXN1 deletions. 21285140

2011

Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker CTD_human This remodeling might contribute to reelin- and GAD(67)-promoter demethylation and might reverse the GABAergic-gene-expression downregulation associated with SZ morbidity. 19110320

2009

Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker CTD_human Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. 18583979

2008

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker CTD_human No allele of the -1438A/G polymorphism of the 5-HT2A gene was transmitted in excess (50 transmitted for 38 untransmitted) in the whole sample of patients with schizophrenia (p = .90). 18513383

2008

Entrez Id: 4842
Gene Symbol: NOS1
NOS1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker CTD_human Altered expression of genes involved in GABAergic transmission and neuromodulation of granule cell activity in the cerebellum of schizophrenia patients. 18923069

2008

Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker CTD_human We employed SDS-PAGE and Western blotting to measure levels of GAD isomers 65 and 67 kDa and Reelin isoforms 410-, 330- and 180-kDa proteins as well as beta-actin in cerebellum of subjects with schizophrenia, bipolar disorder and major depression vs. controls (N = 15 per group). 15560956

2005

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker CTD_human Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. 14708030

2004

Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker CTD_human In addition, reelin protein in the molecular layer of the dentate gyrus was decreased in schizophrenia, bipolar disorder, and depression at the trend level of statistical significance (P=0.065). 14708030

2004

Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker CTD_human We present new immunocytochemical evidence showing reductions in Reelin expression in hippocampus of subjects with schizophrenia, bipolar disorder and major depression and confirm recent reports documenting a similar deficit involving Reelin expression in brains of subjects with schizophrenia and bipolar disorder. 11126396

2000

Entrez Id: 85358
Gene Symbol: SHANK3
SHANK3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker CTD_human

Entrez Id: 65078
Gene Symbol: RTN4R
RTN4R
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.670 Biomarker CTD_human

Entrez Id: 6671
Gene Symbol: SP4
SP4
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.660 Biomarker CTD_human The human SP4 gene is therefore examined for its association with both bipolar disorder and schizophrenia in European Caucasian and Chinese populations respectively. 19401786

2009

Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker CTD_human Taken into account that increased Glycogen Synthase Kinase 3 Beta (GSK-3β) activity is associated with schizophrenia pathophysiology and certain antipsychotics can be able to decrease GSK3β activity, inhibition of GSK-3β activity could be a novel approach for the treatment of schizophrenia. 31563592

2019

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker CTD_human Association of Disrupted in Schizophrenia 1 (DISC1) missense variants with ultra-resistant schizophrenia. 20531374

2011

Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker CTD_human Recently, an (AAT)n triplet repeat polymorphism within the cannabinoid receptor gene CNR1 has been found to be associated with both schizophrenia and substance dependence, and to modulate the P300 potential. 21513772

2011

Entrez Id: 10718
Gene Symbol: NRG3
NRG3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker CTD_human RNA expression profiling of these isoforms in the prefrontal cortex of 400 individuals revealed that NRG3 expression is developmentally regulated and pathologically increased in schizophrenia. 20713722

2010

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker CTD_human Therefore, genes associated with schizophrenia, including neuregulin-1 (NRG1), catechol-O-methyltranferase (COMT) and disrupted-in-schizophrenia-1 (DISC1), may play a role in modulating the physiological and psychological effects of pain stimuli in such patients. 20561508

2010

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker CTD_human Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. 18583979

2008