Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9863
Gene Symbol: MAGI2
MAGI2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.850 Biomarker PSYGENET One of the rare CNVs found in SZ cohorts is the duplication of Synaptic Scaffolding Molecule (S-SCAM, also called MAGI-2), which encodes a postsynaptic scaffolding protein controlling synaptic AMPA receptor levels, and thus the strength of excitatory synaptic transmission. 25653350

2015

Entrez Id: 9863
Gene Symbol: MAGI2
MAGI2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.850 Biomarker PSYGENET In conclusion, although we could not detect strong genetic evidence for association of common variants in MAGI2 and increased schizophrenia risk in a Japanese population, these SNPs may increase risk of cognitive impairment in schizophrenic patients. 22649501

2012

Entrez Id: 9863
Gene Symbol: MAGI2
MAGI2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.850 Biomarker PSYGENET Because earlier work had identified a CNV in the close relative MAGI2 in SZ, the study was extended to include MAGI2. 22381734

2012

Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET These results underline the relevance of the risk "A" allele to neurocognitive functioning and suggest that its detrimental effects on cognition, may be part of the mechanism by which the CSMD1 mediates risk for schizophrenia. 24630139

2014

Entrez Id: 1139
Gene Symbol: CHRNA7
CHRNA7
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET The α7 nicotinic acetylcholine receptor gene (CHRNA7) is linked to schizophrenia. 25056953

2014

Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET A post hoc analysis of loci significantly associated with psychiatric disorders suggested that genetic variation at CSMD1, a schizophrenia susceptibility locus, plays a role in the ratio between dopamine and serotonin metabolites in CSF. 23319000

2014

Entrez Id: 6925
Gene Symbol: TCF4
TCF4
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET The analyses on the 28 individual SNPs previously associated with schizophrenia found that two SNPs in TCF4 returned a significant association with the SPEQ Paranoia dimension, rs17512836 (p-value = 2.57×10⁻⁴) and rs9960767 (p-value = 6.23×10⁻⁴). 24718684

2014

Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET In particular, our two-stage strategy found association in both our combined case/control analysis and the family-based analysis on 1q21.2 (closest gene: sphingosine-1-phosphate receptor 1 gene, S1PR1) and on 1q24.1 near the gene TMCO1, and at CSMD1 on 8p23.2, supporting several previous GWAS reports for BD and for schizophrenia. 24387768

2014

Entrez Id: 6925
Gene Symbol: TCF4
TCF4
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure. 25217366

2014

Entrez Id: 6925
Gene Symbol: TCF4
TCF4
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET Single nucleotide polymorphisms in TCF4 gene have been consistently associated with schizophrenia in genome wide association studies, including the C allele of rs9960767. 24275585

2014

Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET In accordance with previous evidence, these data suggest that CSMD1 may mediate brain function related to cognitive processes (i.e., executive function); with the relatively deleterious effects of the identified "A" risk allele on brain activity possibly constituting part of the mechanism by which CSMD1 increases schizophrenia risk. 23839771

2013

Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET Neuropsychological deficits in mice depleted of the schizophrenia susceptibility gene CSMD1. 24244513

2013

Entrez Id: 6925
Gene Symbol: TCF4
TCF4
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET Genome-wide association studies have also found that common variants in TCF4 are associated with an increased risk of schizophrenia. 24058414

2013

Entrez Id: 1139
Gene Symbol: CHRNA7
CHRNA7
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET The purpose of the current study was to explore the association of auditory P50 sensory gating (P50) and prepulse inhibition (PPI) of schizophrenia with polymorphisms in the CHRNA7 and COMT genes. 23598060

2013

Entrez Id: 63826
Gene Symbol: SRR
SRR
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion. 22801410

2013

Entrez Id: 1139
Gene Symbol: CHRNA7
CHRNA7
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET Two SNPs in CHRNA7 were associated with schizophrenia in African-Americans, and a second SNP in CHRNA7 was significant for an association with smoking and smoking in schizophrenia in Caucasians. 21970977

2012

Entrez Id: 1139
Gene Symbol: CHRNA7
CHRNA7
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET The CHRNA7 gene, which encodes the α7 nicotinic acetylcholine receptor (α7*nAChR), has been implicated as a candidate gene in schizophrenia. 21979958

2011

Entrez Id: 63826
Gene Symbol: SRR
SRR
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET This study demonstrates that aberrant Srr function and diminished d-serine may contribute to schizophrenia pathogenesis. 19483194

2009

Entrez Id: 63826
Gene Symbol: SRR
SRR
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET The IVS1a+465C allele of the SRR gene, which reduces expression of the gene, is a risk factor for schizophrenia, especially the paranoid subtype. 17067558

2007

Entrez Id: 63826
Gene Symbol: SRR
SRR
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET The SRR/DAO are not likely to be major genetic determinants in the development of schizophrenia or control of serum D-serine levels. 15953485

2005

Entrez Id: 9739
Gene Symbol: SETD1A
SETD1A
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.650 Biomarker PSYGENET We identify two de novo LOF variants in the SETD1A gene, which encodes a subunit of histone methyltransferase, a finding unlikely to have occurred by chance, and provide evidence for a more general role of chromatin regulators in schizophrenia risk. 24853937

2014

Entrez Id: 8831
Gene Symbol: SYNGAP1
SYNGAP1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.630 Biomarker PSYGENET Reduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of Schizophrenia. 19145222

2009

Entrez Id: 5534
Gene Symbol: PPP3R1
PPP3R1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.630 Biomarker PSYGENET Forebrain-specific CNB knockout mice display a spectrum of behavioral abnormalities related to altered behaviors observed in schizophrenia patients. 12851458

2003

Entrez Id: 4192
Gene Symbol: MDK
MDK
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.620 Biomarker PSYGENET Genetic variation in a region on chromosome 11 that contains the candidate genes AMBRA1, DGKZ, CHRM4 and MDK was significantly associated with SCZ in the combined sample (n=11 540; P=3.89 × 10(-9), odds ratio (OR)=1.25). 21747397

2012

Entrez Id: 84152
Gene Symbol: PPP1R1B
PPP1R1B
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker PSYGENET Our results suggest that variation in PPP1R1B affects the abundance of the splice variant t-DARPP-32 mRNA and may reflect potential molecular mechanisms implicated in schizophrenia and affective disorders. 23295814

2014