Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.700 Biomarker LHGDN Association of ERBB2 gene status with histopathological parameters and disease-specific survival in gastric carcinoma patients. 19156142

2009
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.700 AlteredExpression LHGDN Impact of insulin-like growth factor type 1 receptor, epidermal growth factor receptor, and HER2 expressions on outcomes of patients with gastric cancer. 18483367

2008
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.700 Biomarker LHGDN HER-2/neu amplification is an independent prognostic factor in gastric cancer. 16868827

2006
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.700 AlteredExpression LHGDN Role of receptor tyrosine kinases in gastric cancer: new targets for a selective therapy. 16733844

2006
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.700 Biomarker LHGDN Potential prognostic significance of p185(HER2) overexpression with loss of PTEN expression in gastric carcinomas. 16457151

2006
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.700 AlteredExpression LHGDN Membranous levels of c-erbB-2 oncoprotein in gastric cancer: their relationship with clinicopathological parameters and their prognostic significance. 15646832

2005
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.700 AlteredExpression LHGDN Coamplified and overexpressed genes at ERBB2 locus in gastric cancer. 14991576

2004
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.700 GeneticVariation LHGDN A single nucleotide polymorphism in the transmembrane domain coding region of HER-2 is associated with development and malignant phenotype of gastric cancer. 14520697

2003
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.620 AlteredExpression LHGDN FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival. 18381441

2008
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.620 PosttranslationalModification LHGDN Aberrant hypermethylation of the FGFR2 gene in human gastric cancer cell lines. 17459342

2007
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.620 AlteredExpression LHGDN Mutations of PIK3CA in gastric adenocarcinoma. 15784156

2005
Entrez Id: 1316
Gene Symbol: KLF6
KLF6
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.610 GeneticVariation LHGDN Genetic alterations of the KLF6 gene in gastric cancer. 15824733

2005
Entrez Id: 4595
Gene Symbol: MUTYH
MUTYH
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.610 GeneticVariation LHGDN Genetic alterations of the MYH gene in gastric cancer. 15273732

2004
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.600 AlteredExpression LHGDN The NMD mRNA surveillance pathway downregulates aberrant E-cadherin transcripts in gastric cancer cells and in CDH1 mutation carriers. 18427545

2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.600 Biomarker LHGDN Positive association of up-regulated Cripto-1 and down-regulated E-cadherin with tumour progression and poor prognosis in gastric cancer. 18312357

2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.600 GeneticVariation LHGDN A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: a case control study in an Italian population. 18482459

2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.600 GeneticVariation LHGDN Hereditary diffuse gastric cancer: association with lobular breast cancer. 18046629

2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.600 AlteredExpression LHGDN Enhancer of zeste homolog 2 downregulates E-cadherin by mediating histone H3 methylation in gastric cancer cells. 18377425

2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.600 GeneticVariation LHGDN Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer. 17545690

2007
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.600 GeneticVariation LHGDN Association between CDH1 haplotypes and gastric cancer risk in a Japanese population. 17852867

2007
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.600 GeneticVariation LHGDN Single nucleotide polymorphisms in the promoter region of the E-cadherin gene in gastric cancer: case-control study in a young Mexican population. 17549573

2007
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.600 Biomarker LHGDN Association of extracellular cleavage of E-cadherin mediated by MMP-7 with HGF-induced in vitro invasion in human stomach cancer cells. 17396032

2007
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.600 GeneticVariation LHGDN E-cadherin and hereditary diffuse gastric cancer. 17981184

2007
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.600 GeneticVariation LHGDN Germline E-cadherin mutations in familial lobular breast cancer. 17660459

2007
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.600 GeneticVariation LHGDN Hereditary diffuse gastric cancer and E-cadherin: description of the first germline mutation in an Italian family. 17126523

2007