Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.350 Biomarker PSYGENET Regression analyses indicated that patients with the A/A genotype for the IL-10 -1082 polymorphism (lower IL-10 producers) reported significantly greater depressive symptoms than G allele carriers (higher IL-10 producers; b = 0.22, P = 0.011), even after controlling for relevant covariates. 22424164

2012

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.330 Biomarker PSYGENET Previous studies have revealed the association of the ACE gene insertion/deletion polymorphism with depressive disorder and its treatment response but not with the depressive symptoms in schizophrenia. 25694211

2015

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.330 Biomarker PSYGENET Association of a polymorphism in the indoleamine- 2,3-dioxygenase gene and interferon-α-induced depression in patients with chronic hepatitis C. 21691274

2012

Entrez Id: 6817
Gene Symbol: SULT1A1
SULT1A1
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.330 Biomarker PSYGENET There were significant interactions between SULT1A1*3 and hot flashes (P < 0.001) and between SULT1A1*2 and depressive symptoms (P = 0.007) on menopausal stage, and there were race-specific effects of SULT1A1*2, SULT1A1*3, CYP1B1*3, and CYP3A4*1B on menopause. 20505544

2011

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.320 Biomarker PSYGENET The CC genotype of transforming growth factor-β1 increases the risk of late-onset Alzheimer's disease and is associated with AD-related depression. 21924590

2012

Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.320 Biomarker PSYGENET Our preliminary results suggest that the SERPINE1 promoter polymorphisms may be associated with antidepressant treatment, but not with the increased susceptibility to the depressive symptoms in AD. 22503724

2012

Entrez Id: 1432
Gene Symbol: MAPK14
MAPK14
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.320 Biomarker PSYGENET Taken together, these findings indicate that sensitivity of p38 MAPK signaling pathways to immune stimulation is associated with depressive symptoms during chronic IFN-alpha treatment. 21356304

2011

Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.320 Biomarker PSYGENET In Japanese women, the odds of depressive symptoms were nearly 5-fold higher among those with CYP 19 rs936306 TT genotype (95% CI, 1.10 to 22.17) than in women with the CC genotype and 9.6-fold higher (95% CI, 2.01 to 45.81) than in women with the CT genotype. 16949393

2006

Entrez Id: 3787
Gene Symbol: KCNS1
KCNS1
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.310 Biomarker PSYGENET There was moderate statistical evidence for interactions for other shoulder pain phenotypes between additional genes (ADRB2, AVPR1 A, and KCNS1) and depressive symptoms, pain catastrophizing, or kinesiophobia. 24373571

2014

Entrez Id: 10060
Gene Symbol: ABCC9
ABCC9
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.310 Biomarker PSYGENET There was also a significant association between a different ABCC9 gene variant (rs11046205) and depressive symptoms. 23780892

2013

Entrez Id: 8871
Gene Symbol: SYNJ2
SYNJ2
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.310 Biomarker PSYGENET No SNPs were associated with the personality and psychological distress traits at a Bonferroni corrected level of significance (P < 0.0002), but there was an over-representation of nominally significant (P < 0.05) SNPs in the synaptojanin-2 (SYNJ2) gene associated with agreeableness and symptoms of depression. 22213687

2012

Entrez Id: 344148
Gene Symbol: NCKAP5
NCKAP5
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.310 Biomarker PSYGENET An association between symptoms of depression and rs7582472 (near to MGAT5 and NCKAP5) was replicated in two independent samples, but other replication findings were less consistent. 22628180

2012

Entrez Id: 10587
Gene Symbol: TXNRD2
TXNRD2
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.310 Biomarker PSYGENET Six SNPs from the first of three COMT/TXNRD2 haploblocks interacted with depressive symptoms on TMD pain (smallest p-value: 2.7 × 10(-10) ). 22337325

2012

Entrez Id: 2194
Gene Symbol: FASN
FASN
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.310 Biomarker PSYGENET Val1483Ile polymorphism in the fatty acid synthase gene was associated with depressive symptoms under the influence of psychological stress. 21641044

2011

Entrez Id: 1545
Gene Symbol: CYP1B1
CYP1B1
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.310 Biomarker PSYGENET There were significant interactions between SULT1A1*3 and hot flashes (P < 0.001) and between SULT1A1*2 and depressive symptoms (P = 0.007) on menopausal stage, and there were race-specific effects of SULT1A1*2, SULT1A1*3, CYP1B1*3, and CYP3A4*1B on menopause. 20505544

2011

Entrez Id: 551
Gene Symbol: AVP
AVP
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.310 Biomarker PSYGENET Our studies indicate that the AVP and its V1b receptor system may be a potential therapeutic target for treating anxiety and depressive symptoms associated with cocaine addiction. 21677651

2011

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.310 Biomarker PSYGENET In conclusion, our results show that genetic variance in the VDR gene influences the susceptibility to age-related changes in cognitive functioning and in depressive symptoms. 17714831

2009

Entrez Id: 163
Gene Symbol: AP2B1
AP2B1
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.310 Biomarker PSYGENET AP-2 beta genotype interacted significantly both with type of housing and parental separation to predict depressive symptoms. 19184334

2009

Entrez Id: 4397
Gene Symbol: MS
MS
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.310 Biomarker PSYGENET To evaluate ApoE alleles in relation to symptoms of depression in a cohort of patients with MS participating in the Sonya Slifka Longitudinal Multiple Sclerosis Study (Slifka Study). 19244396

2009

Entrez Id: 2332
Gene Symbol: FMR1
FMR1
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.310 Biomarker PSYGENET To define better this neuropsychiatric phenotype associated with premutation carriers and to minimize a possible environmental effect, we examined psychiatric and depressive symptoms in 34 FMR1 premutation carrier mothers of children with fragile-X syndrome in comparison with two control groups (39 mothers with a non-fragile-X syndrome mentally retarded child and 39 mothers from the general population). 18628675

2008

Entrez Id: 1610
Gene Symbol: DAO
DAO
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.310 Biomarker PSYGENET These data suggest a potential role for DAO in susceptibility to depressive symptoms in schizophrenia, but a more general role for DAO in affective disorders cannot be excluded. 17890006

2007

Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.310 Biomarker PSYGENET Among Caucasian women, those with the CYP1A1 rs2606345 CC and AC genotypes had approximately 2-fold greater odds of having depressive symptoms than did those with the AA genotype (95% confidence intervals [CIs], 1.33 to 4.66 and 1.25 to 3.14, respectively). 16949393

2006

Entrez Id: 60482
Gene Symbol: SLC5A7
SLC5A7
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.310 Biomarker PSYGENET Our previous work has shown genetic variation in the human choline transporter gene (CHT1) to be associated with depressive symptoms and autonomic cardiac (cholinergic) dysregulation. 16876130

2006

Entrez Id: 3454
Gene Symbol: IFNAR1
IFNAR1
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.310 Biomarker PSYGENET This preliminary result suggests that the promoter GT repeat dinucleotide microsatellite polymorphism of the IFNAR1 gene may represent a risk factor for the development of depressive symptoms during IFN-alpha therapy for hepatitis C and other conditions. 15990456

2005

Entrez Id: 79953
Gene Symbol: SYNDIG1
SYNDIG1
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms
0.300 Biomarker PSYGENET Namely, R3HDML and C20orf39 are significantly associated with depressive symptoms of schizophrenia (P(emp)<2×10⁻⁵) based on the minimum P-value and truncated-product methods, respectively. 22220189

2011