Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Therapeutic RGD Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury. 29498696

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Therapeutic RGD Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury. 29498696

2018

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Therapeutic RGD Protective effect of naringenin in experimental ischemic stroke: down-regulated NOD2, RIP2, NF-κB, MMP-9 and up-regulated claudin-5 expression. 24842554

2014

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Therapeutic RGD Hypertonic saline alleviates cerebral edema by inhibiting microglia-derived TNF-α and IL-1β-induced Na-K-Cl Cotransporter up-regulation. 24916922

2014

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Biomarker RGD Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)-piperazine dihydro-chloride on inflammation after stroke. 23028794

2012

Entrez Id: 718
Gene Symbol: C3
C3
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Biomarker RGD Proteomic analysis of rat plasma following transient focal cerebral ischemia. 22103620

2011

Entrez Id: 5327
Gene Symbol: PLAT
PLAT
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Biomarker RGD Temporal profile of tissue plasminogen activator (tPA) and inhibitor expression after transient focal cerebral ischemia. 14512838

2003

Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.210 Therapeutic RGD 4'-O-β-D-Glucosyl-5-O-Methylvisamminol, A Natural Histone H3 Phosphorylation Epigenetic Suppressor, Exerts a Neuroprotective Effect Through PI3K/Akt Signaling Pathway on Focal Cerebral Ischemia in Rats. 26868427

2016

Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.210 Therapeutic RGD Nicotinamide prevents the down-regulation of MEK/ERK/p90RSK signaling cascade in brain ischemic injury. 21891976

2012

Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.210 Therapeutic RGD By improving regional cortical blood flow, attenuating mitochondrial dysfunction and sequential apoptosis galangin acts as a potential neuroprotective agent after acute ischemic stroke. 23143152

2012

Entrez Id: 6558
Gene Symbol: SLC12A2
SLC12A2
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.210 Therapeutic RGD Inhibition of Na(+)-K(+)-Cl(-) cotransporter during focal cerebral ischemia decreases edema and neuronal damage. 12535773

2003

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD The combination of 31409163

2020

Entrez Id: 6548
Gene Symbol: SLC9A1
SLC9A1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Neurovascular protection in voltage-gated proton channel Hv1 knock-out rats after ischemic stroke: interaction with Na 31250553

2019

Entrez Id: 84329
Gene Symbol: HVCN1
HVCN1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Neurovascular protection in voltage-gated proton channel Hv1 knock-out rats after ischemic stroke: interaction with Na 31250553

2019

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury. 29498696

2018

Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD (-)-Phenserine inhibits neuronal apoptosis following ischemia/reperfusion injury. 28963051

2017

Entrez Id: 10135
Gene Symbol: NAMPT
NAMPT
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Hyperbaric Oxygen Reduces Infarction Volume and Hemorrhagic Transformation Through ATP/NAD+/Sirt1 Pathway in Hyperglycemic Middle Cerebral Artery Occlusion Rats. 28495827

2017

Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Role of glycogen synthase kinase 3 in ischemia-induced blood-brain barrier disruption in aged female rats. 28440874

2017

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Tau-mediated iron export prevents ferroptotic damage after ischemic stroke. 28886009

2017

Entrez Id: 839
Gene Symbol: CASP6
CASP6
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD 4'-O-β-D-Glucosyl-5-O-Methylvisamminol, A Natural Histone H3 Phosphorylation Epigenetic Suppressor, Exerts a Neuroprotective Effect Through PI3K/Akt Signaling Pathway on Focal Cerebral Ischemia in Rats. 26868427

2016

Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7β-Aurora A pathway. 27152455

2016

Entrez Id: 842
Gene Symbol: CASP9
CASP9
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD 4'-O-β-D-Glucosyl-5-O-Methylvisamminol, A Natural Histone H3 Phosphorylation Epigenetic Suppressor, Exerts a Neuroprotective Effect Through PI3K/Akt Signaling Pathway on Focal Cerebral Ischemia in Rats. 26868427

2016

Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7β-Aurora A pathway. 27152455

2016

Entrez Id: 142
Gene Symbol: PARP1
PARP1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Nuclear-translocated Glyceraldehyde-3-phosphate Dehydrogenase Promotes Poly(ADP-ribose) Polymerase-1 Activation during Oxidative/Nitrosative Stress in Stroke. 25882840

2015

Entrez Id: 2597
Gene Symbol: GAPDH
GAPDH
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Nuclear-translocated Glyceraldehyde-3-phosphate Dehydrogenase Promotes Poly(ADP-ribose) Polymerase-1 Activation during Oxidative/Nitrosative Stress in Stroke. 25882840

2015