Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Therapeutic RGD Hypertonic saline alleviates cerebral edema by inhibiting microglia-derived TNF-α and IL-1β-induced Na-K-Cl Cotransporter up-regulation. 24916922

2014

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Therapeutic RGD Protective effect of naringenin in experimental ischemic stroke: down-regulated NOD2, RIP2, NF-κB, MMP-9 and up-regulated claudin-5 expression. 24842554

2014

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Biomarker RGD Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)-piperazine dihydro-chloride on inflammation after stroke. 23028794

2013

Entrez Id: 718
Gene Symbol: C3
C3
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Biomarker RGD Proteomic analysis of rat plasma following transient focal cerebral ischemia. 22103620

2012

Entrez Id: 5327
Gene Symbol: PLAT
PLAT
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Biomarker RGD Temporal profile of tissue plasminogen activator (tPA) and inhibitor expression after transient focal cerebral ischemia. 14512838

2004

Entrez Id: 3662
Gene Symbol: IRF4
IRF4
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Expression of interleukin-9 and its upstream stimulating factors in rats with ischemic stroke. 25652434

2016

Entrez Id: 1728
Gene Symbol: NQO1
NQO1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Danhong injection attenuates ischemia/reperfusion-induced brain damage which is associating with Nrf2 levels in vivo and in vitro. 25069640

2015

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Lipoxin A4 ameliorates cerebral ischaemia/reperfusion injury through upregulation of nuclear factor erythroid 2-related factor 2. 23880501

2014

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Eriodictyol-7-O-glucoside activates Nrf2 and protects against cerebral ischemic injury. 24466583

2014

Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Transcriptomics of post-stroke angiogenesis in the aged brain. 24672479

2014

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Enalapril attenuates ischaemic brain oedema and protects the blood-brain barrier in rats via an anti-oxidant action. 24471927

2014

Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Bicyclol upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia. 24252362

2014

Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD The expression of angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas receptor axis are upregulated after acute cerebral ischemic stroke in rats. 24090950

2014

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Hypertonic saline alleviates cerebral edema by inhibiting microglia-derived TNF-α and IL-1β-induced Na-K-Cl Cotransporter up-regulation. 24916922

2014

Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Heme oxygenase-1 mediated memorial and revivable protective effect of ischemic preconditioning on brain injury. 23870531

2014

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Neamine induces neuroprotection after acute ischemic stroke in type one diabetic rats. 24211797

2014

Entrez Id: 7122
Gene Symbol: CLDN5
CLDN5
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Protective effect of naringenin in experimental ischemic stroke: down-regulated NOD2, RIP2, NF-κB, MMP-9 and up-regulated claudin-5 expression. 24842554

2014

Entrez Id: 2475
Gene Symbol: MTOR
MTOR
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Ischemic post-conditioning facilitates brain recovery after stroke by promoting Akt/mTOR activity in nude rats. 23777415

2014

Entrez Id: 1965
Gene Symbol: EIF2S1
EIF2S1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Pinocembrin protects brain against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress induced apoptosis. 23669639

2014

Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD The expression of angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas receptor axis are upregulated after acute cerebral ischemic stroke in rats. 24090950

2014

Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Protective effect of treatment with low-dose gliclazide in a model of middle cerebral artery occlusion and reperfusion in rats. 24602692

2014

Entrez Id: 2475
Gene Symbol: MTOR
MTOR
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways. 24583056

2014

Entrez Id: 64127
Gene Symbol: NOD2
NOD2
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Protective effect of naringenin in experimental ischemic stroke: down-regulated NOD2, RIP2, NF-κB, MMP-9 and up-regulated claudin-5 expression. 24842554

2014

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)-piperazine dihydro-chloride on inflammation after stroke. 23028794

2013

Entrez Id: 8772
Gene Symbol: FADD
FADD
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Effect of Danshen aqueous extract on serum hs-CRP, IL-8, IL-10, TNF-α levels, and IL-10 mRNA, TNF-α mRNA expression levels, cerebral TGF-β1 positive expression level and its neuroprotective mechanisms in CIR rats. 23378241

2013