|
| Entrez Id: |
2956 |
| Gene Symbol: |
MSH6 |
MSH6
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.520 |
Biomarker |
CLINGEN |
Hereditary cancer-associated missense mutations in hMSH6 uncouple ATP hydrolysis from DNA mismatch binding.
|
18790734 |
2008 |
|
| Entrez Id: |
2956 |
| Gene Symbol: |
MSH6 |
MSH6
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.520 |
Biomarker |
CLINGEN |
Molecular and clinical characteristics of MSH6 variants: an analysis of 25 index carriers of a germline variant.
|
11709755 |
2002 |
|
| Entrez Id: |
2956 |
| Gene Symbol: |
MSH6 |
MSH6
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.520 |
Biomarker |
CLINGEN |
MSH6 and MSH3 are rarely involved in genetic predisposition to nonpolypotic colon cancer.
|
11245474 |
2001 |
|
| Entrez Id: |
2956 |
| Gene Symbol: |
MSH6 |
MSH6
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.520 |
Biomarker |
CLINGEN |
HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions.
|
10545954 |
1999 |
|
| Entrez Id: |
2956 |
| Gene Symbol: |
MSH6 |
MSH6
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.520 |
Biomarker |
CLINGEN |
Association of hereditary nonpolyposis colorectal cancer-related tumors displaying low microsatellite instability with MSH6 germline mutations.
|
10521294 |
1999 |
|
| Entrez Id: |
2956 |
| Gene Symbol: |
MSH6 |
MSH6
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.520 |
Biomarker |
CLINGEN |
Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer.
|
9354786 |
1997 |
|
| Entrez Id: |
2956 |
| Gene Symbol: |
MSH6 |
MSH6
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.520 |
Biomarker |
CLINGEN |
Mutation in the mismatch repair gene Msh6 causes cancer susceptibility.
|
9390556 |
1997 |
|
| Entrez Id: |
2956 |
| Gene Symbol: |
MSH6 |
MSH6
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.520 |
Biomarker |
CLINGEN |
GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells.
|
7604265 |
1995 |
|
| Entrez Id: |
2956 |
| Gene Symbol: |
MSH6 |
MSH6
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.520 |
Biomarker |
CLINGEN |
Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells.
|
7604264 |
1995 |
|
| Entrez Id: |
4436 |
| Gene Symbol: |
MSH2 |
MSH2
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.500 |
Biomarker |
CLINGEN |
Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer.
|
27329137 |
2016 |
|
| Entrez Id: |
22909 |
| Gene Symbol: |
FAN1 |
FAN1
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.500 |
Biomarker |
CLINGEN |
Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability.
|
26797144 |
2016 |
|
| Entrez Id: |
5395 |
| Gene Symbol: |
PMS2 |
PMS2
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.500 |
Biomarker |
CLINGEN |
Lynch syndrome caused by germline PMS2 mutations: delineating the cancer risk.
|
25512458 |
2015 |
|
| Entrez Id: |
22909 |
| Gene Symbol: |
FAN1 |
FAN1
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.500 |
Biomarker |
CLINGEN |
Germline Mutations in FAN1 Cause Hereditary Colorectal Cancer by Impairing DNA Repair.
|
26052075 |
2015 |
|
| Entrez Id: |
4436 |
| Gene Symbol: |
MSH2 |
MSH2
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.500 |
Biomarker |
CLINGEN |
Cancer risks for MLH1 and MSH2 mutation carriers.
|
23255516 |
2013 |
|
| Entrez Id: |
5395 |
| Gene Symbol: |
PMS2 |
PMS2
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.500 |
Biomarker |
CLINGEN |
Deficient expression of DNA repair enzymes in early progression to sporadic colon cancer.
|
22494821 |
2012 |
|
| Entrez Id: |
22909 |
| Gene Symbol: |
FAN1 |
FAN1
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.500 |
Biomarker |
CLINGEN |
Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.
|
20603016 |
2010 |
|
| Entrez Id: |
22909 |
| Gene Symbol: |
FAN1 |
FAN1
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.500 |
Biomarker |
CLINGEN |
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.
|
20603073 |
2010 |
|
| Entrez Id: |
5395 |
| Gene Symbol: |
PMS2 |
PMS2
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.500 |
Biomarker |
CLINGEN |
PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance.
|
20624957 |
2010 |
|
| Entrez Id: |
27030 |
| Gene Symbol: |
MLH3 |
MLH3
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.500 |
Biomarker |
CLINGEN |
Biochemical characterization of MLH3 missense mutations does not reveal an apparent role of MLH3 in Lynch syndrome.
|
19156873 |
2009 |
|
| Entrez Id: |
27030 |
| Gene Symbol: |
MLH3 |
MLH3
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.500 |
Biomarker |
CLINGEN |
Evidence that hMLH3 functions primarily in meiosis and in hMSH2-hMSH3 mismatch repair.
|
19483466 |
2009 |
|
| Entrez Id: |
5395 |
| Gene Symbol: |
PMS2 |
PMS2
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.500 |
Biomarker |
CLINGEN |
The clinical phenotype of Lynch syndrome due to germ-line PMS2 mutations.
|
18602922 |
2008 |
|
| Entrez Id: |
27030 |
| Gene Symbol: |
MLH3 |
MLH3
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.500 |
Biomarker |
CLINGEN |
The first functional study of MLH3 mutations found in cancer patients.
|
18521850 |
2008 |
|
| Entrez Id: |
27030 |
| Gene Symbol: |
MLH3 |
MLH3
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.500 |
Biomarker |
CLINGEN |
Conditional nuclear localization of hMLH3 suggests a minor activity in mismatch repair and supports its role as a low-risk gene in HNPCC.
|
17203173 |
2007 |
|
| Entrez Id: |
5395 |
| Gene Symbol: |
PMS2 |
PMS2
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.500 |
Biomarker |
CLINGEN |
Long-range PCR facilitates the identification of PMS2-specific mutations.
|
16619239 |
2006 |
|
| Entrez Id: |
4436 |
| Gene Symbol: |
MSH2 |
MSH2
|
Hereditary non-polyposis colorectal cancer syndrome
|
0.500 |
Biomarker |
CLINGEN |
Pathogenicity of MSH2 missense mutations is typically associated with impaired repair capability of the mutated protein.
|
17101317 |
2006 |