Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 761
Gene Symbol: CA3
CA3
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.500 Biomarker CTD_human Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model. 25231249

2015

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.500 Biomarker CTD_human Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. 20623750

2011

Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.340 Biomarker CTD_human Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury. 28762043

2018

Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.340 Biomarker CTD_human Effects of CYP inhibitors on precocene I metabolism and toxicity in rat liver slices. 21741958

2011

Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.340 Biomarker CTD_human CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis. 16770646

2006

Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.340 Biomarker CTD_human The aim of this study was to evaluate whether the polymorphism of the CYP2E1 gene is associated with antituberculosis drug-induced hepatitis. 12668988

2003

Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.330 Biomarker CTD_human Key factors of susceptibility to anti-tuberculosis drug-induced hepatotoxicity. 25693865

2015

Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.330 Biomarker CTD_human Genetic polymorphisms of NAT2 and CYP2E1 associated with antituberculosis drug-induced hepatotoxicity in Korean patients with pulmonary tuberculosis. 17950035

2007

Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.330 Biomarker CTD_human Verified predominance of slow acetylator phenotype N-acetyltransferase 2 (NAT2) in a Hmong population residing in Minnesota. 16799928

2006

Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.330 Biomarker CTD_human To determine whether acetylator status is a risk factor for antituberculosis drug-induced hepatitis, we genotyped NAT2 in 224 incident tuberculosis patients who received antituberculosis treatment. 11915035

2002

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.310 Therapeutic CTD_human Nrf2 Activation Ameliorates Hepatotoxicity Induced by a Heme Synthesis Inhibitor. 30215777

2019

Entrez Id: 1555
Gene Symbol: CYP2B6
CYP2B6
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.310 Biomarker CTD_human Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury. 28762043

2018

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.310 Therapeutic CTD_human P450 3A-Catalyzed O-Dealkylation of Lapatinib Induces Mitochondrial Stress and Activates Nrf2. 26958860

2016

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.310 Therapeutic CTD_human Nrf2 protects against furosemide-induced hepatotoxicity. 24813929

2014

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.310 Biomarker CTD_human Amiodarone exposure during modest inflammation induces idiosyncrasy-like liver injury in rats: role of tumor necrosis factor-alpha. 21984482

2012

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.310 Therapeutic CTD_human Amiodarone exposure during modest inflammation induces idiosyncrasy-like liver injury in rats: role of tumor necrosis factor-alpha. 21984482

2012

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.310 Therapeutic CTD_human Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation. 22627062

2012

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.310 Therapeutic CTD_human Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury. 22491424

2012

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.310 Biomarker CTD_human Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. 20623750

2011

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.310 Therapeutic CTD_human Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. 20623750

2011

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.310 Therapeutic CTD_human Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity. 19638433

2009

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.310 Biomarker CTD_human Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity. 19638433

2009

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.310 Therapeutic CTD_human Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha. 17709330

2007

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.310 Biomarker CTD_human Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha. 17709330

2007

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.310 Biomarker CTD_human Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure. 9696492

1998