Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET The FKBP5 rs1360780 polymorphism is associated with plasma cortisol and FKBP5 mRNA expression after psychosocial stress in healthy controls but not in remitted depression. 25522420

2015

Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET The FK506-binding protein 51 (FKBP51, encoded by the FKBP5 gene) is an established risk factor for stress-related psychiatric disorders such as major depression. 25436518

2015

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Our findings provide empirical evidence that the 5-HTR2A rs6313 T>C and rs7997012 G>A polymorphism may be correlated with the efficacy of antidepressants in the treatment of MDD. 25108775

2015

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Serotonin 2A receptor (HTR2A) gene was implicated to be associated with major depressive disorder (MDD) susceptibility due to its role of key neurotransmitter in many physiologic processes. 25270656

2015

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Single locus analysis in pooled and ethnically stratified subjects revealed no association between each of the three variants of the TPH2 gene with susceptibility to MDD. 24376086

2015

Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Therefore, the results suggest that accumulation of the GR in cytoplasm is related to the elevation of FKBP5, adding one more step in understanding altered GR signalling in lymphocytes, and potentially brain tissue, of MDD patients. 25355489

2015

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Those with both the 5-HTTLPR s allele and the BDNF Met allele showed the highest risk of MD if they had previously experienced emotional (z = 2.08, p = 0.037), sexual (z = 2.19, p = 0.029) or any kind of childhood abuse (z = 2.37, p = 0.018). 25510949

2015

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET This translational and ecological study involving constitutive Htr2a(-/-) knock-out mice and related SNPs in depressed patients suggests that a lower neurotransmission at the 5-HT2AR may favor the susceptibility and severity of MDE. 24801750

2015

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET This analysis suggests that DNA hypomethylation of the 5-HTT transcriptional control region - possibly via increased serotonin transporter expression and consecutively decreased serotonin availability - might impair antidepressant treatment response in Caucasian patients with MDD. 24679990

2015

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Our results suggest that a NET 182C and 5-HTTLPR polymorphism interaction is associated with susceptibility to treatment resistant depression and ECT treatment response in antidepressant resistant depression patients. 25650523

2015

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET A number of studies have assessed a relationship between the T102C polymorphism in the HTR2A gene with an increased risk of major depressive disorder (MDD), bipolar disorder (BPD), and schizophrenia (SCZ). 24962835

2015

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET The results of our analysis indicated no significant differences in the frequencies of the single alleles and genotypes of two polymorphisms in TPH2 gene between LOD patients and normal controls. 26057341

2015

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET This review highlights some research studying changes in the epigenetic patterns intrinsic to genes of 5-HTT and BDNF, which are related to lifelong environmental adversities, which in turn increases the risks of developing MDD. 24972302

2015

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET 5-HTTLPR genotype may also impact upon other regions of the brain, such as the OFC, but structural differences in these regions in early adolescence may not necessarily alter the risk for onset of depression during later adolescence. 25226554

2015

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Polymorphisms of CRHR1 and AVPR1b may modify susceptibility to mood disorders. 23962971

2014

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Polymorphisms in the gene encoding the serotonin synthesis enzyme Tph2 have been identified in mental illnesses, including bipolar disorder, major depression, autism, schizophrenia, and ADHD. 24196946

2014

Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET We have observed an association between five FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) and major depressive disorder (p=0.011; p=0.007, p=0.038; p=0.030; p=0.018, respectively), but not bipolar disorder. 24856550

2014

Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET The aims of this study were to clarify the role of the FKBP5 gene in depression and anxiety disorders through a case-control study and an association study with personality traits using the Temperament and Character Inventory (TCI) in healthy subjects. 23861224

2014

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET The aim of this prospective study was to examine whether the 5-HT2A receptor -1438 G/A polymorphism has functional consequences on sexual well-being in young adult men presenting with their first episode of major depressive disorder (MDD) after serotonergic antidepressant treatment. 22612784

2014

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Here we use chronic multicircuit neurophysiological recordings to characterize functional interactions across cortical and limbic circuits in mice engineered to express a human loss-of-function depression allele Tph2-(R441H) [Tph2 knockin (Tph2KI)]. 23467366

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Only rs4792888 in CRHR1 showed modest evidence of association with duloxetine response in MDD (P=0.029 in GAD, P=0.054 in MDD). 22249355

2013

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET A rare mutation in tryptophan hydroxylase 2 (Tph2), the rate limiting enzyme for 5-HT synthesis, was identified in several patients with major depression, and knock-in mice expressing the analogous mutation (R439H Tph2 KI) show 80% reduction in 5-HT synthesis and tissue levels. 23336047

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV. 23157339

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET These results suggest that the CRHR1 gene could modify the susceptibility to developing recurrent MDD following negative life events in adulthood. 23529111

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET These results provide support for an association of CRHR1 and CRHR2 with MDD and PD. 22467522

2012