Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Therapeutic CTD_human Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. 25822088

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker CTD_human Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. 25822088

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Therapeutic CTD_human Most HCC are associated with chronic infection by Hepatitis B Virus while a G → T mutation at codon 249 of the TP53 gene, R249S, specific for exposure to aflatoxin, is detected in tumors for up to 30% of cases. 22675488

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker CTD_human Most HCC are associated with chronic infection by Hepatitis B Virus while a G → T mutation at codon 249 of the TP53 gene, R249S, specific for exposure to aflatoxin, is detected in tumors for up to 30% of cases. 22675488

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker CTD_human We have therefore generated 'knock-in' mouse embryonic stem (ES) cells to investigate the effects of expressing a commonly found hot-spot p53 mutant, R246S -- the mouse equivalent of human R249S, which is associated with hepatocellular carcinomas. 18477611

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Therapeutic CTD_human We have therefore generated 'knock-in' mouse embryonic stem (ES) cells to investigate the effects of expressing a commonly found hot-spot p53 mutant, R246S -- the mouse equivalent of human R249S, which is associated with hepatocellular carcinomas. 18477611

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker CTD_human These results suggest the level of p53 expression could determine if the HCC cells would go into cell cycle arrest or apoptosis. 17191126

2007

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Therapeutic CTD_human These results suggest the level of p53 expression could determine if the HCC cells would go into cell cycle arrest or apoptosis. 17191126

2007

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Therapeutic CTD_human Molecular biological analyses of the induced lesions revealed point mutations in the p53 gene in 60.9% of HCCs, and elevated expression of mRNAs for p53, c-myc, c-fos, TGF-alpha, TGF-beta1, alpha-fetoprotein, GST-P, and GGT, and decreased mRNA expression of EGF and EGFR in HCCs when compared to controls. 9029167

1997

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker CTD_human Molecular biological analyses of the induced lesions revealed point mutations in the p53 gene in 60.9% of HCCs, and elevated expression of mRNAs for p53, c-myc, c-fos, TGF-alpha, TGF-beta1, alpha-fetoprotein, GST-P, and GGT, and decreased mRNA expression of EGF and EGFR in HCCs when compared to controls. 9029167

1997

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker CTD_human Frequent and specific mutations of the rat p53 gene in hepatocarcinomas induced by tamoxifen. 8033108

1994

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Therapeutic CTD_human Frequent and specific mutations of the rat p53 gene in hepatocarcinomas induced by tamoxifen. 8033108

1994

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
1.000 Biomarker CTD_human

Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.900 Biomarker CTD_human

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker CTD_human Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling. 28284560

2017

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker CTD_human The present study indicates that miR-885-5p suppresses the metastasis of HCC and inhibits Wnt/β-catenin signaling pathway by its CTNNB1 target, which suggests that miR-885-5p to be a promising negative regulator of HCC progression and as a novel therapeutic agent to treat HCC. 27738331

2016

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker CTD_human Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. 25822088

2015

Entrez Id: 8312
Gene Symbol: AXIN1
AXIN1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker CTD_human Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. 25822088

2015

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker CTD_human Gene expression and mutation assessment provide clues of genetic and epigenetic mechanisms in liver tumors of oxazepam-exposed mice. 21147764

2011

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker CTD_human Activation of beta-catenin in mouse hepatoma cells activates GSTm3 promoter-driven reporter activity, independently of beta-catenin/T-cell factor sites, via a retinoid X receptor-binding site. 20118494

2010

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.800 Biomarker CTD_human

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 Biomarker CTD_human Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling. 28284560

2017

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 Biomarker CTD_human Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. 25822088

2015

Entrez Id: 3481
Gene Symbol: IGF2
IGF2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 Biomarker CTD_human It may be concluded that IGF II gene expression plays an important role during the development of neoplasia and the gene expresses in the sequence of events leading from glycogen-rich-acidophilic lesions to glycogen poor basophilic lesions to HCC with an expression pattern of "high-low-high" in terms of degree of expression. 16092956

2005

Entrez Id: 3482
Gene Symbol: IGF2R
IGF2R
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 Biomarker CTD_human Total RNA was extracted from individual HCCs for assessment of mutations within exons 27, 28, 31, 33, and 34, and aberrant transcript of the M6p/Igf2r gene by reverse transcription (RT)-polymerase chain reaction (PCR)-single strand conformation polymorphism (SSCP) and RT-PCR analyses, respectively. 15057872

2004