Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.300 Biomarker RGD Oral sorbent AST-120 increases renal NO synthesis in uremic rats. 18089446

2008

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.300 Therapeutic RGD Carbonic adsorbent AST-120 retards progression of renal failure by additive effect with ACEI and protein restriction diet. 14586729

2003

Entrez Id: 1234
Gene Symbol: CCR5
CCR5
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.250 Biomarker RGD Role of FTY720 on M1 and M2 macrophages, lymphocytes, and chemokines in 5/6 nephrectomized rats. 19535570

2009

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.240 Therapeutic RGD Effect of exercise on cardiac tissue oxidative and inflammatory mediators in chronic kidney disease. 18797164

2009

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.240 Biomarker RGD Expression of monocyte chemoattractant protein-1 in proximal tubular epithelial cells in a rat model of progressive kidney failure. 12080327

2002

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.240 Biomarker RGD Only animals from the 1WIK group developed severe chronic renal failure, glomerulosclerosis, interstitial fibrosis, and upregulation of transforming growth factor-beta(1) (TGF-beta(1)) gene, which was associated with increased TGF-beta(1) protein expression in tubular epithelial cells, arterioles, and in areas of mononuclear interstitial cell infiltrate. 10919844

2000

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.230 Biomarker RGD Changes of adiponectin and its receptors in rats following chronic renal failure. 24028144

2014

Entrez Id: 51094
Gene Symbol: ADIPOR1
ADIPOR1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.230 Biomarker RGD Changes of adiponectin and its receptors in rats following chronic renal failure. 24028144

2014

Entrez Id: 5741
Gene Symbol: PTH
PTH
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.230 Biomarker RGD Two novel vitamin D receptor modulators with similar structures exhibit different hypercalcemic effects in 5/6 nephrectomized uremic rats. 23548814

2013

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.230 Biomarker RGD Curcumin and enalapril ameliorate renal failure by antagonizing inflammation in 5/6 nephrectomized rats: role of phospholipase and cyclooxygenase. 22031851

2012

Entrez Id: 57817
Gene Symbol: HAMP
HAMP
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.230 Biomarker RGD Erythropoietin regulates intestinal iron absorption in a rat model of chronic renal failure. 20631677

2011

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.230 Biomarker RGD Multiple antioxidants and L-arginine modulate inflammation and dyslipidemia in chronic renal failure rats. 20199183

2010

Entrez Id: 4842
Gene Symbol: NOS1
NOS1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.220 Therapeutic RGD [Effects of shenshuai II recipe on the protein expressions of Ang II and nNOS in chronic renal failure rats' nephridial tissue]. 23185775

2014

Entrez Id: 4842
Gene Symbol: NOS1
NOS1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.220 Biomarker RGD Vitamin E reduces glomerulosclerosis, restores renal neuronal NOS, and suppresses oxidative stress in the 5/6 nephrectomized rat. 17200156

2007

Entrez Id: 9365
Gene Symbol: KL
KL
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.220 Biomarker RGD This is the first report showing the expression of the klotho gene in the kidney is regulated under sustained circulatory stress such as long-term hypertension, diabetes mellitus, and chronic renal failure. 9731228

1998

Entrez Id: 1906
Gene Symbol: EDN1
EDN1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.220 Biomarker RGD Renal endothelin gene expression is increased in remnant kidney and correlates with disease progression. 8441230

1993

Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.210 Therapeutic RGD An integrated lipidomics and metabolomics reveal nephroprotective effect and biochemical mechanism of Rheum officinale in chronic renal failure. 26903149

2017

Entrez Id: 79602
Gene Symbol: ADIPOR2
ADIPOR2
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.210 Biomarker RGD Changes of adiponectin and its receptors in rats following chronic renal failure. 24028144

2014

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.210 Therapeutic RGD Epoetin delta as an antifibrotic agent in the remnant kidney rat: a possible role for transforming growth factor beta and hepatocyte growth factor. 20424483

2010

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.210 Biomarker RGD Role of FTY720 on M1 and M2 macrophages, lymphocytes, and chemokines in 5/6 nephrectomized rats. 19535570

2009

Entrez Id: 1535
Gene Symbol: CYBA
CYBA
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.210 Biomarker RGD Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure. 19420110

2009

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.210 Biomarker RGD Down-regulation of intestinal drug transporters in chronic renal failure in rats. 17135344

2007

Entrez Id: 2057
Gene Symbol: EPOR
EPOR
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Down-Regulation of Cardiac Erythropoietin Receptor and its Downstream Activated Signal Transducer Phospho-STAT-5 in a Rat Model of Chronic Kidney Disease. 27468524

2016

Entrez Id: 664
Gene Symbol: BNIP3
BNIP3
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach. 24090408

2014

Entrez Id: 8678
Gene Symbol: BECN1
BECN1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach. 24090408

2014