Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension
0.500 Therapeutic RGD In "prevention" therapy, BH<sub>4</sub> (10 and 100 mg/kg) attenuated the development of PH in rat MCT model. eNOS protein levels in lung homogenates were maintained and cGMP levels were increased. 29151278

2018

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension
0.500 Biomarker RGD Epigenetic regulation of the endothelial nitric oxide synthase gene in persistent pulmonary hypertension of the newborn rat. 20724942

2010

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension
0.500 Biomarker RGD L-arginine may act through three pathways, providing a substrate for NO generation, preserving eNOS expression/phosphorylation, and maintaining the association of eNOS and HSP90, which allows restoration of eNOS activity and coupling activity, to maintain the balance between NO and O(2)(*-) and delay the development of PH. 20215577

2010

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension
0.500 Biomarker RGD Sleeping Beauty-mediated eNOS gene therapy attenuates monocrotaline-induced pulmonary hypertension in rats. 17065228

2006