Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Biomarker RGD The present study aimed to investigate the repercussions of CRF on intestinal transporters involved in drug absorption [organic anion-transportingpolypeptide (Oatp)] and those implicated in drug extrusion (Pgp and MRP2). 17135344

2007

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Biomarker RGD Pgp, MRP2, MRP3, Oatp2, and Oatp3 protein expression and Pgp, MRP2, and Oatp3 mRNA expression were assessed in the intestine of CRF (induced by five-sixth nephrectomy) and control rats. 17135344

2007

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Biomarker RGD Our results demonstrate that CRF in rats is associated with a decrease in intestinal Pgp and MRP2 protein expression and function secondarily to serum uremic factors. 17135344

2007

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.210 Biomarker RGD Protein expression of Pgp, MRP2, and MRP3 were reduced by more than 40% (p < 0.01) in CRF rats, whereas Oatp2 and Oatp3 expression remained unchanged. 17135344

2007