Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6721
Gene Symbol: SREBF2
SREBF2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD In CRF rats, a twofold increase in SREBP-2 mRNA level, as well as in mature SREBP-2 protein abundance was found, when compared to control animals. 16814791

2007

Entrez Id: 6721
Gene Symbol: SREBF2
SREBF2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD Despite increased SREBP-2 gene expression we found LDL-receptor mRNA level to be lower than in controls, suggesting SREBP-2 independent mechanisms of LDL-receptor transcriptional regulation in CRF rats. 16814791

2007

Entrez Id: 6721
Gene Symbol: SREBF2
SREBF2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD Increased gene expression of liver SREBP-2 in experimental chronic renal failure. 16814791

2007

Entrez Id: 6721
Gene Symbol: SREBF2
SREBF2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD Therefore, increased level of SREBP-2 could be responsible for hypercholesterolemia, which is observed in experimental chronic renal failure (CRF). 16814791

2007

Entrez Id: 6721
Gene Symbol: SREBF2
SREBF2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD We conclude that experimental CRF is associated with increased liver SREBP-2 gene expression. 16814791

2007

Entrez Id: 6721
Gene Symbol: SREBF2
SREBF2
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic
0.500 Biomarker RGD This study was designed primary to evaluate the impact of experimental CRF (5/6 nephrectomy model) on rat liver SREBP-2 gene expression. 16814791

2007