Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 695
Gene Symbol: BTK
BTK
CUI: C0221026
Disease: X-linked agammaglobulinemia
X-linked agammaglobulinemia 		1.000 Biomarker MGD OBF-1 is essential for the generation of antibody-secreting cells and the development of autoimmunity in MRL-lpr mice. 17574818

2007
Entrez Id: 695
Gene Symbol: BTK
BTK
CUI: C0221026
Disease: X-linked agammaglobulinemia
X-linked agammaglobulinemia 		1.000 Biomarker MGD Tumor suppressor function of Bruton tyrosine kinase is independent of its catalytic activity. 15331445

2005
Entrez Id: 695
Gene Symbol: BTK
BTK
CUI: C0221026
Disease: X-linked agammaglobulinemia
X-linked agammaglobulinemia 		1.000 Biomarker MGD Function of Bruton's tyrosine kinase during B cell development is partially independent of its catalytic activity. 14634110

2003
Entrez Id: 695
Gene Symbol: BTK
BTK
CUI: C0221026
Disease: X-linked agammaglobulinemia
X-linked agammaglobulinemia 		1.000 Biomarker MGD Impaired B cell maturation in mice lacking Bruton's tyrosine kinase (Btk) and CD40. 9088978

1997
Entrez Id: 695
Gene Symbol: BTK
BTK
CUI: C0221026
Disease: X-linked agammaglobulinemia
X-linked agammaglobulinemia 		1.000 Biomarker MGD Bruton's tyrosine kinase (Btk) is a cytoplasmic protein kinase that is defective in X-linked agammaglobulinaemia in man and in X-linked immunodeficiency in the mouse. 8890160

1996
Entrez Id: 695
Gene Symbol: BTK
BTK
CUI: C0221026
Disease: X-linked agammaglobulinemia
X-linked agammaglobulinemia 		1.000 Biomarker MGD Mutations in the Bruton's tyrosine kinase (Btk) gene have been linked to severe early B cell developmental blocks in human X-linked agammaglobulinemia (XLA), and to milder B cell activation deficiencies in murine X-linked immune deficiency (Xid). 7552994

1995
Entrez Id: 695
Gene Symbol: BTK
BTK
CUI: C0221026
Disease: X-linked agammaglobulinemia
X-linked agammaglobulinemia 		1.000 Biomarker MGD B lymphocyte production in the bone marrow of mice with X-linked immunodeficiency (xid). 3875649

1985
Entrez Id: 695
Gene Symbol: BTK
BTK
CUI: C0221026
Disease: X-linked agammaglobulinemia
X-linked agammaglobulinemia 		1.000 Biomarker MGD X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells. 805203

1975