Source: CLINGEN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0009405
Disease: Hereditary Nonpolyposis Colorectal Neoplasms
Hereditary Nonpolyposis Colorectal Neoplasms 		0.300 Biomarker CLINGEN Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer. 28135145

2017
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0009405
Disease: Hereditary Nonpolyposis Colorectal Neoplasms
Hereditary Nonpolyposis Colorectal Neoplasms 		0.300 Biomarker CLINGEN Homozygous inactivation of CHEK2 is linked to a familial case of multiple primary lung cancer with accompanying cancers in other organs. 27900359

2016
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0009405
Disease: Hereditary Nonpolyposis Colorectal Neoplasms
Hereditary Nonpolyposis Colorectal Neoplasms 		0.300 Biomarker CLINGEN Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells. 24976383

2014
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0009405
Disease: Hereditary Nonpolyposis Colorectal Neoplasms
Hereditary Nonpolyposis Colorectal Neoplasms 		0.300 Biomarker CLINGEN Meta-analysis of CHEK2 1100delC variant and colorectal cancer susceptibility. 21807500

2011
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0009405
Disease: Hereditary Nonpolyposis Colorectal Neoplasms
Hereditary Nonpolyposis Colorectal Neoplasms 		0.300 Biomarker CLINGEN CHEK2 mutations and HNPCC-related colorectal cancer. 19876921

2010
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0009405
Disease: Hereditary Nonpolyposis Colorectal Neoplasms
Hereditary Nonpolyposis Colorectal Neoplasms 		0.300 Biomarker CLINGEN The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population. 18996005

2009
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0009405
Disease: Hereditary Nonpolyposis Colorectal Neoplasms
Hereditary Nonpolyposis Colorectal Neoplasms 		0.300 Biomarker CLINGEN CHEK2 1100delC is a susceptibility allele for HNPCC-related colorectal cancer. 18676774

2008
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0009405
Disease: Hereditary Nonpolyposis Colorectal Neoplasms
Hereditary Nonpolyposis Colorectal Neoplasms 		0.300 Biomarker CLINGEN Alterations of Chk1 and Chk2 expression in colon cancer. 18679694

2008
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0009405
Disease: Hereditary Nonpolyposis Colorectal Neoplasms
Hereditary Nonpolyposis Colorectal Neoplasms 		0.300 Biomarker CLINGEN DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response. 16478982

2006
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0009405
Disease: Hereditary Nonpolyposis Colorectal Neoplasms
Hereditary Nonpolyposis Colorectal Neoplasms 		0.300 Biomarker CLINGEN Homozygosity for a CHEK2*1100delC mutation identified in familial colorectal cancer does not lead to a severe clinical phenotype. 15818573

2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0009405
Disease: Hereditary Nonpolyposis Colorectal Neoplasms
Hereditary Nonpolyposis Colorectal Neoplasms 		0.300 Biomarker CLINGEN DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. 15829956

2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0009405
Disease: Hereditary Nonpolyposis Colorectal Neoplasms
Hereditary Nonpolyposis Colorectal Neoplasms 		0.300 Biomarker CLINGEN The CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype. 12690581

2003