Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 84464
Gene Symbol: SLX4
SLX4
CUI: C0346153
Disease: Breast Cancer, Familial
Breast Cancer, Familial
0.330 Biomarker CLINGEN Next-generation sequencing in familial breast cancer patients from Lebanon. 28202063

2017

Entrez Id: 84464
Gene Symbol: SLX4
SLX4
CUI: C0346153
Disease: Breast Cancer, Familial
Breast Cancer, Familial
0.330 Biomarker CLINGEN Mouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease XPF-ERCC1 in DNA crosslink repair. 24726326

2014

Entrez Id: 84464
Gene Symbol: SLX4
SLX4
CUI: C0346153
Disease: Breast Cancer, Familial
Breast Cancer, Familial
0.330 Biomarker CLINGEN Clinical evaluation of a multiple-gene sequencing panel for hereditary cancer risk assessment. 24733792

2014

Entrez Id: 84464
Gene Symbol: SLX4
SLX4
CUI: C0346153
Disease: Breast Cancer, Familial
Breast Cancer, Familial
0.330 Biomarker CLINGEN Although this is the first study that describes a truncating SLX4 mutation in breast cancer patients, our data indicate that germline mutations in SLX4 are very rare and are unlikely to make a significant contribution to familial breast cancer. 22911665

2013

Entrez Id: 84464
Gene Symbol: SLX4
SLX4
CUI: C0346153
Disease: Breast Cancer, Familial
Breast Cancer, Familial
0.330 Biomarker CLINGEN Low prevalence of SLX4 loss-of-function mutations in non-BRCA1/2 breast and/or ovarian cancer families. 23211700

2013

Entrez Id: 84464
Gene Symbol: SLX4
SLX4
CUI: C0346153
Disease: Breast Cancer, Familial
Breast Cancer, Familial
0.330 Biomarker CLINGEN Assessment of SLX4 Mutations in Hereditary Breast Cancers. 23840564

2013

Entrez Id: 84464
Gene Symbol: SLX4
SLX4
CUI: C0346153
Disease: Breast Cancer, Familial
Breast Cancer, Familial
0.330 Biomarker CLINGEN Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia. 21240276

2011

Entrez Id: 84464
Gene Symbol: SLX4
SLX4
CUI: C0346153
Disease: Breast Cancer, Familial
Breast Cancer, Familial
0.330 Biomarker CLINGEN SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype. 21240277

2011