×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011 2016
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011 2016
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Meta-analysis of BRAF mutation as a predictive biomarker of benefit from anti-EGFR monoclonal antibody therapy for RAS wild-type metastatic colorectal cancer.
25989278 2015
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.
24163374 2014
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
BRAFV600E mutation and its association with clinicopathological features of colorectal cancer: a systematic review and meta-analysis.
24594804 2014
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
25157968 2014
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Vemurafenib synergizes with nutlin-3 to deplete survivin and suppresses melanoma viability and tumor growth.
23812671 2013
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.
23845441 2013
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Massively parallel tumor multigene sequencing to evaluate response to panitumumab in a randomized phase III study of metastatic colorectal cancer.
23325582 2013
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
BRAF V600E is a determinant of sensitivity to proteasome inhibitors.
24107445 2013
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer.
23549875 2013
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents.
23251002 2013
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma.
22535154 2012
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.
22281684 2012
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer.
22180495 2012
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
The road to resistance: EGFR mutation and cetuximab.
22310681 2012
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial.
22608338 2012
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib.
22448344 2012
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
BRAF V600E mutation and resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer: a meta-analysis.
20857202 2011
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
BRAF as a target for cancer therapy.
21426297 2011
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer.
21163703 2011
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
BRAF, p53 and SOX2 in anaplastic thyroid carcinoma: evidence for multistep carcinogenesis.
21716161 2011
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma.
21343559 2011
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma.
21190184 2011
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis.
20619739 2010