×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Cardio-facio-cutaneous syndrome
0.800
GeneticVariation
CLINVAR
High resolution melting analysis of KRAS, BRAF and PIK3CA in KRAS exon 2 wild-type metastatic colorectal cancer.
23548132
2013
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Cardio-facio-cutaneous syndrome
0.800
GeneticVariation
CLINVAR
Diverging gain-of-function mechanisms of two novel KRAS mutations associated with Noonan and cardio-facio-cutaneous syndromes.
23059812
2013
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Cardio-facio-cutaneous syndrome
0.800
GeneticVariation
CLINVAR
Two novel germline KRAS mutations: expanding the molecular and clinical phenotype.
21797849
2012
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Cardio-facio-cutaneous syndrome
0.800
GeneticVariation
CLINVAR
The importance of evaluation of DNA amplificability in KRAS mutation testing with dideoxy sequencing using formalin-fixed and paraffin-embedded colorectal cancer tissues.
20926413
2011
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Cardio-facio-cutaneous syndrome
0.800
GeneticVariation
CLINVAR
In conclusion, our data underscore the important role of RAS in the pathogenesis of the group of related disorders including NS, CFCS , and CS, and provide clues to the high phenotypic variability of patients with germline KRAS mutations.
20949621
2011
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Cardio-facio-cutaneous syndrome
0.800
CausalMutation
CLINVAR
In conclusion, our data underscore the important role of RAS in the pathogenesis of the group of related disorders including NS, CFCS , and CS, and provide clues to the high phenotypic variability of patients with germline KRAS mutations.
20949621
2011
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Cardio-facio-cutaneous syndrome
0.800
GeneticVariation
CLINVAR
Craniosynostosis in patients with Noonan syndrome caused by germline KRAS mutations.
19396835
2009
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Cardio-facio-cutaneous syndrome
0.800
CausalMutation
CLINVAR
Noonan syndrome caused by germline KRAS mutation in Taiwan: report of two patients and a review of the literature.
18958496
2009
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Cardio-facio-cutaneous syndrome
0.800
GeneticVariation
CLINVAR
Noonan syndrome caused by germline KRAS mutation in Taiwan: report of two patients and a review of the literature.
18958496
2009
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Cardio-facio-cutaneous syndrome
0.800
CausalMutation
CLINVAR
PTPN11, SOS1, KRAS, and RAF1 gene analysis, and genotype-phenotype correlation in Korean patients with Noonan syndrome.
19020799
2008
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Cardio-facio-cutaneous syndrome
0.800
CausalMutation
CLINVAR
Mutations were identified in seven patients with CFC (two in BRAF, one in KRAS , one in MEK1, two in MEK2 and one in SOS1).
18456719
2008
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Cardio-facio-cutaneous syndrome
0.800
CausalMutation
CLINVAR
Congenital ulcerating hemangioma in a baby with KRAS mutation and cardio-facio-cutaneous syndrome.
17551339
2007
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Cardio-facio-cutaneous syndrome
0.800
GeneticVariation
CLINVAR
We further defined the phenotypic spectrum associated with KRAS missense mutations and provided the first evidence of clinical differences in patients with KRAS mutations compared with Noonan syndrome affected individuals with heterozygous PTPN11 mutations and CFC patients carrying a BRAF, MEK1 or MEK1 alteration, respectively.
17056636
2007
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Cardio-facio-cutaneous syndrome
0.800
CausalMutation
CLINVAR
Cardio-facio-cutaneous and Noonan syndromes due to mutations in the RAS/MAPK signalling pathway: genotype-phenotype relationships and overlap with Costello syndrome.
17704260
2007
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Cardio-facio-cutaneous syndrome
0.800
CausalMutation
CLINVAR
We further defined the phenotypic spectrum associated with KRAS missense mutations and provided the first evidence of clinical differences in patients with KRAS mutations compared with Noonan syndrome affected individuals with heterozygous PTPN11 mutations and CFC patients carrying a BRAF, MEK1 or MEK1 alteration, respectively.
17056636
2007
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Cardio-facio-cutaneous syndrome
0.800
CausalMutation
CLINVAR
Biochemical and functional characterization of germ line KRAS mutations.
17875937
2007
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Cardio-facio-cutaneous syndrome
0.800
GeneticVariation
CLINVAR
Biochemical and functional characterization of germ line KRAS mutations.
17875937
2007
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Cardio-facio-cutaneous syndrome
0.800
GeneticVariation
CLINVAR
Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome .
16474404
2006
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Cardio-facio-cutaneous syndrome
0.800
GeneticVariation
CLINVAR
Germline KRAS mutations cause Noonan syndrome.
16474405
2006
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Cardio-facio-cutaneous syndrome
0.800
CausalMutation
CLINVAR
Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome .
16474404
2006
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Cardio-facio-cutaneous syndrome
0.800
CausalMutation
CLINVAR
Germline KRAS mutations cause Noonan syndrome.
16474405
2006
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Cardio-facio-cutaneous syndrome
0.800
CausalMutation
CLINVAR
Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype.
16773572
2006
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Cardio-facio-cutaneous syndrome
0.800
GeneticVariation
CLINVAR
Effector domain mutations dissociate p21ras effector function and GTPase-activating protein interaction.
8246952
1993
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Cardio-facio-cutaneous syndrome
0.800
GeneticVariation
CLINVAR
Probing the role of loop 2 in Ras function with unnatural amino acids.
8234268
1993