Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker LHGDN Increased immunoreactivity of EGF-R and moderate immunoreactivity of TGF-alpha was detected in adenocarcinomas. 18054376

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN Mutations in EGFR were found only in adenocarcinoma (35 of 106 adenocarcinoma), mainly in females (73%). 18334834

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker LHGDN The goal was to evaluate the copy number alterations of several oncogene loci, including 7p12 [epidermal growth factor receptor (EGFR)], 8q24 (c-myc), and 20q13 in the sequence of no dysplasia-dysplasia-adenocarcinoma of Barrett's esophagus. 18559552

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN In this prospective study, EGFR exon 19 deletion or L858R mutations in adenocarcinoma were the best predictors for longer TTF in stage IIIB/IV chemotherapy-naive NSCLC patients receiving first-line gefitinib monotherapy. 18509184

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN Sequential molecular changes during multistage pathogenesis of small peripheral adenocarcinomas of the lung. 18379350

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN Radiotherapy in lung adenocarcinoma with brain metastases: effects of activating epidermal growth factor receptor mutations on clinical response. 18172267

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 AlteredExpression LHGDN Epidermal growth factor receptor signaling in adenocarcinomas with bronchioloalveolar components. 18154814

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN Epidermal growth factor receptor (EGFR) high gene copy number and activating mutations in lung adenocarcinomas are not consistently accompanied by positivity for EGFR protein by standard immunohistochemistry. 18258923

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN EGFR mutations predict survival benefit from gefitinib in patients with advanced lung adenocarcinoma: a historical comparison of patients treated before and after gefitinib approval in Japan. 18794545

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN These observations suggest that the germline EGFR V843I mutation might have altered EGFR signaling in the multicentric development of adenocarcinoma, bronchoalveolar carcinoma, and atypical adenomatous hyperplasia and also might have had a role in the development of lung cancer in multiple members of her family. 18355544

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN Tumors with BAC components carried more frequently EGFR mutations compared to adenocarcinomas without BAC histology (17/70=24% vs 3/50=6.0%; p=0.012). 18450321

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 AlteredExpression LHGDN Role of epidermal growth factor gene in the development of pancreatic cancer and efficiency of inhibitors of this gene in the treatment of pancreatic carcinoma. 19110611

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN Tissue heterogeneity of EGFR mutation in lung adenocarcinoma. 18449007

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN Prognostic and therapeutic implications of EGFR and KRAS mutations in resected lung adenocarcinoma. 18303429

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN Adenocarcinoma with epidermal growth factor receptor gene mutations in three siblings. 18317075

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN The present study suggests that increased expression of erbB3 may play an additional role in NSCLC especially in female, nonsmoker, adenocarcinoma, and with EGFR gene mutation. 17631905

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN In EGFR-mutant adenocarcinoma metastases, the higher levels of EGFR overexpression and more homogeneously distributed high gene copy numbers suggest tumor progression. 19138956

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN Mutations of EGFR and K-ras genes represent an early event in lung adenocarcinomagenesis, and AAH convincingly seems to be a precursor lesion in a subset of cases of adenocarcinoma. 18208799

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker LHGDN There was a statistically significant increase in the proportion of cases with gains of EGFR in squamous cell carcinomas (SCC), compared with adenocarcinomas (AC) (82 vs. 43%, respectively; P = 0.017), and a higher average EGFR gene copy number in the SCCs than in the ACs (5.04 vs. 3.78, respectively; P = 0.013) in 41 NSCLCs. 18558286

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN Mutations of the exon 19 of EGFR gene were higher in female, non-smoking and adenocarcinoma patients. 18543225

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 AlteredExpression LHGDN EGFR was expressed in 33 of 103 adenocarcinomas (32%) and was correlated with higher pathologic tumor (T) classification (P = .02), the presence of lymph node metastasis (P = .01), and higher pathologic tumor, lymph node, metastasis classification (P = .02). 17211865

2007

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 AlteredExpression LHGDN Coexpression of epidermal growth factor receptor (EGFR) and the HER-2 oncoprotein has been reported to be related to the invasion and an adverse clinical outcome of human pancreatic ductal adenocarcinomas. 17549361

2007

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN Among adenocarcinomas, nonmucinous and mucinous BAC components were significantly associated with EGFR and K-ras gene mutations, respectively. 17580276

2007

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN EGFR mutation was identified in 6 of 54 cases studied and all 6 cases were TRU-type adenocarcinomas. 17721266

2007

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 AlteredExpression LHGDN Yet neither the spectrum of tissue expression nor the signalling pathways of OPN in MM and pulmonary adenocarcinoma have been characterized, although in vitro evidence links OPN to the epidermal growth factor receptor (EGFR) pathway. 17493236

2007