Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.400 GeneticVariation LHGDN In the present review we discuss recent findings showing that, in addition to the canonical estrogen receptor-alpha (ERalpha), the level of various ERalpha splice variants is changed in the human brain in aging and Alzheimer's disease (AD) at both the mRNA and protein level and that they should be considered for the understanding of estrogen effects on the brain and estrogen therapy pitfalls. 18210333

2008

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.400 AlteredExpression LHGDN We examined the relation of polymorphisms in ESR1 to the risk of AD in women with Down syndrome. 18408366

2008

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.400 GeneticVariation LHGDN Interaction between estrogen receptor-alpha and butyrylcholinesterase genes modulates Alzheimer's disease risk. 17410321

2007

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.400 GeneticVariation LHGDN Estrogen receptor-alpha splice variants in the medial mamillary nucleus of Alzheimer's disease patients: identification of a novel MB1 isoform. 15755860

2005

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.400 Biomarker LHGDN Changes in estrogen receptor-alpha and -beta in the infundibular nucleus of the human hypothalamus are related to the occurrence of Alzheimer's disease neuropathology. 15070964

2004