Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0003130
Disease: Anoxia
Anoxia
0.050 AlteredExpression LHGDN In conclusion, PCAF regulates the balance between cell-cycle arrest and apoptosis in hypoxia by modulating the activity and protein stability of both p53 and HIF-1alpha. 18574470

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0003130
Disease: Anoxia
Anoxia
0.050 Biomarker LHGDN Cardiac angiogenesis played an important role in the maintenance of cardiac function as well as the development of cardiac hypertrophy induced by pressure-overload, and upregulated p53 induced the transition from cardiac hypertrophy to heart failure through the suppression of hypoxia inducible factor-1(HIF-1), which regulates angiogenesis in the hypertrophied heart. 18464525

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0003130
Disease: Anoxia
Anoxia
0.050 Biomarker LHGDN Interestingly, however, DNA damage combined with hypoxia modulated both the intensity of the p53 response and the composition of downstream target genes. 18087215

2007

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0003130
Disease: Anoxia
Anoxia
0.050 AlteredExpression LHGDN However, we found that Fas/CD95 was significantly induced in response to hypoxia in a p53-dependent manner, along with several novel p53 target genes including ANXA1, DDIT3/GADD153 (CHOP), SEL1L and SMURF1. 16917513

2007

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0003130
Disease: Anoxia
Anoxia
0.050 AlteredExpression LHGDN Besides HIF-1, the transcription factor and tumour suppressor p53 accumulates and is activated under conditions of prolonged/severe hypoxia. 14992692

2004