Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN an RNA switch in human vascular endothelial growth factor-A mRNA 3'untranslated region that integrates signals from interferon -gamma and hypoxia to regulate VEGFA translation in myeloid cells 19098893

2009

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN results indicate that in progressive but not in stable proteinuric kidney disease, proximal tubular epithelial cells show an attenuated VEGF-A expression despite an activation of intracellular hypoxia response and VEGF signaling pathways 19139726

2009

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 Biomarker LHGDN Quercetin suppressed the HIF-1alpha accumulation during hypoxia in human cancer cell lines and reduced hypoxia-induced secretion of VEGF 18655183

2008

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN We conclude that edaravone inhibits VEGF expression in astrocytes exposed to hypoxia, at least partly, through the down-regulation of HIF-1alpha. 17889387

2008

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 Biomarker LHGDN These results suggest that fludarabine reduces survivability of HepG2 cells via VEGF signaling under hypoxia. 17961496

2007

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN Tumors that constitutively express VEGF-A present with different vascular beds than tumors in which VEGF-A is expressed as a response to central hypoxia. 16804907

2006

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN Normal amounts of BRCA1 function in hypoxia to regulate HIF-1alpha stability, probably by interacting with HIF-1alpha, leading to reduced levels of VEGF. 16543242

2006

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 Biomarker LHGDN Our findings point towards the involvement of excitotoxicity, VEGF and NO in periventricular white matter damage in response to hypoxia 16787408

2006

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 Biomarker LHGDN androgen receptor is involved in VEGF and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer 16278385

2005

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 Biomarker LHGDN VEGF (121) produced a combination of significantly reduced total and perfused vessel spacing, as well as a corresponding reduction in overall tumour hypoxia in MCF-7 breast cancer cells 14735189

2004

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0003130
Disease: Anoxia
Anoxia
0.100 AlteredExpression LHGDN The overexpression of VEGF in hepatocellular carcinoma (HCC) could be promoted by hypoxia and EGF expression in HCC. 15040022

2004