Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation LHGDN Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region. 19116921

2009

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation LHGDN Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci. 19116923

2009

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation LHGDN HLA-DRB1*0404 is strongly associated with high titers of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis. 18799094

2009

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation LHGDN The HLA-DRB1 shared epitope is associated with susceptibility to rheumatoid arthritis in African Americans through European genetic admixture. 18240241

2008

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 Biomarker LHGDN HLA polymorphism and early rheumatoid arthritis in the Moroccan population. 18801688

2008

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation LHGDN Auto-antibodies, HLA and PTPN22: susceptibility markers for rheumatoid arthritis. 18156150

2008

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation LHGDN Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus. 18309376

2008

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 Biomarker LHGDN The HLA-DRB1 shared epitope is not associated with antibodies against cyclic citrullinated peptide in Chinese patients with rheumatoid arthritis. 18465452

2008

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 Biomarker LHGDN Association of the HLA-DRB1 gene with premature death, particularly from cardiovascular disease, in patients with rheumatoid arthritis and inflammatory polyarthritis. 18240242

2008

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation LHGDN Association of DRB1 shared epitope genotypes with early mortality in rheumatoid arthritis: results of eighteen years of followup from the early rheumatoid arthritis study. 17469097

2007

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 Biomarker LHGDN We found that sera of RA patients homozygous for HLA-DRB1*0404 recognised a 100-kDa synovial protein identified as calpastatin. 17324966

2007

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation LHGDN Meta-analysis of HLA-DRB1 polymorphism in Latin American patients with rheumatoid arthritis. 17537386

2007

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 Biomarker LHGDN Meta-analysis of the association between HLA-DRB1 allele and rheumatoid arthritis susceptibility in Asian populations. 18162709

2007

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation LHGDN Differential association of HLA-DRB1 alleles in Japanese patients with early rheumatoid arthritis in relationship to autoantibodies to cyclic citrullinated peptide. 17543145

2007

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 Biomarker LHGDN The HLA-DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide. 17265477

2007

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 Biomarker LHGDN Influence of HLA-DRB1 genes and the shared epitope on genetic susceptibility to rheumatoid arthritis in Taiwanese. 17309132

2007

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation LHGDN HLA-DRB1 and persistent chronic inflammation contribute to cardiovascular events and cardiovascular mortality in patients with rheumatoid arthritis. 17266100

2007

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation LHGDN The association of HLA-DRB1 alleles with rheumatoid arthritis in the Chinese Shantou population: a follow-up study. 17534404

2007

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation LHGDN Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis. 17436241

2007

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 Biomarker LHGDN Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development. 18077428

2007

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation LHGDN Validation of the reshaped shared epitope HLA-DRB1 classification in rheumatoid arthritis. 16646982

2006

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 Biomarker LHGDN Activation of nitric oxide signaling by the rheumatoid arthritis shared epitope. 17075829

2006

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation LHGDN Extensive multiallelic analysis of the relationship between HLA-DRB1 and rheumatoid arthritis using a Bayesian partition model. 16826237

2006

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation LHGDN Prevalence of DRB1*01 and DRB1*04 alleles in a group of patients with rheumatoid arthritis living in Liguria. 16366416

2005

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 Biomarker LHGDN The effect of HLA-DR on susceptibility to rheumatoid arthritis is influenced by the associated lymphotoxin alpha-tumor necrosis factor haplotype. 12528108

2003