Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0004096
Disease: Asthma
Asthma
0.500 GeneticVariation LHGDN So, GRK5-Leu41 represents a gain-of-function polymorphism that evokes enhanced loss-of-function of beta2AR during persistent agonist exposure, and thus may contribute to beta-agonist variability in asthma treatment of African-Americans. 18622265

2008

Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0004096
Disease: Asthma
Asthma
0.500 GeneticVariation LHGDN Clinical consequences of ADRbeta2 polymorphisms. 18303970

2008

Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0004096
Disease: Asthma
Asthma
0.500 GeneticVariation LHGDN [The Arg16Glybeta2-adrenergic receptor polymorphism influences long term clinical responses to beta2-agonist]. 18591903

2008

Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0004096
Disease: Asthma
Asthma
0.500 GeneticVariation LHGDN The effect of polymorphism of the beta-2 adrenergic receptor on the response to beta-2 agonist in bronchial asthma patients. 17297203

2007

Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0004096
Disease: Asthma
Asthma
0.500 GeneticVariation LHGDN Association of haplotypes of beta2-adrenoceptor polymorphisms with lung function and airway responsiveness in a pediatric cohort. 17068824

2006

Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0004096
Disease: Asthma
Asthma
0.500 GeneticVariation LHGDN The aim of this study was to examine the associations between the beta ( 2 ) AR polymorphisms and risks of asthma, chronic obstructive pulmonary disease (COPD) and respiratory symptoms in a sample of adults. 16946993

2006

Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0004096
Disease: Asthma
Asthma
0.500 GeneticVariation LHGDN The Gly16 polymorphism of beta(2)-AR was overrepresented in nocturnal asthmatic patients, correlated with nocturnal asthma, and therefore appeared to be an important genetic factor in the expression of this asthmatic phenotype. 16369120

2006

Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0004096
Disease: Asthma
Asthma
0.500 GeneticVariation LHGDN Our data indicate that ADRB2 does not contribute substantially to susceptibility to asthma, but it is possible that these polymorphisms influence disease activity and drug responses in individuals with asthma. 15153795

2004

Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0004096
Disease: Asthma
Asthma
0.500 GeneticVariation LHGDN Multivariate logistic regression analysis was used to estimate the odds ratio (OR) of the association between beta(2)AR haplotype status and asthma diagnosis. 14657864

2003

Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0004096
Disease: Asthma
Asthma
0.500 GeneticVariation LHGDN In contrast, although not associated with the diagnosis of asthma per se, variant forms of the beta(2)-adrenoceptor (beta2-AR) gene (ADRB2) display functional effects that may be clinically relevant. 12083965

2001