Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 AlteredExpression LHGDN TP53 mutations are common in esophageal squamous cell carcinomas (SCC). 19003964

2009

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 AlteredExpression LHGDN We explored the immunohistochemical expression of FAS, Ki-67 and p53 in squamous cell carcinomas (SCC) of the larynx and their association with clinicopathological features and outcome. 18949744

2009

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 AlteredExpression LHGDN Prognostic value of expression of p53, proliferating cell nuclear antigen, and c-erbB-2 in laryngeal carcinoma. 18509272

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation LHGDN Prognostic significance of TP53 mutations in oral squamous cell carcinoma with human papilloma virus infection. 18161655

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 AlteredExpression LHGDN Reduced membranous beta-catenin protein expression is associated with metastasis and poor prognosis in squamous cell carcinoma of the esophagus. 18455580

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation LHGDN p53 codon 72 polymorphism associated with risk of human papillomavirus-associated squamous cell carcinoma of the oropharynx in never-smokers. 18258602

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation LHGDN Squamous cell carcinomas of the head and neck (HNSCC) often harbor p53 mutations, but p53 protein degradation by the viral oncoprotein E6 may supercede p53 mutations in human papillomavirus 16 (HPV16)-positive tumors. 18223210

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 AlteredExpression LHGDN Head and neck squamous cell carcinoma in non-smoking and non-drinking patients with multiple tumors: etiologic significance of p53 and Ki-67 in non-tumorous epithelium. 18331287

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 Biomarker LHGDN Expression levels of the genes p14(ARF), p15(INK4b), p16(INK4a) and p53 were examined in 16 AKs and 12 SCCs by real-time RT-PCR. 18331779

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 Biomarker LHGDN Strong p53 nuclear staining was detected in STK, SCC and ARK. 18606525

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation LHGDN The results indicate that alterations in both the p53 and p16-Rb pathways are associated with SCC arising in MCT. 19067849

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation LHGDN Two kinds of cell lines were used.These were derived from a human squamous cell carcinoma (SAS) and had identical genetic backgrounds except for their p53 gene status. 19065343

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 AlteredExpression LHGDN The clinicopathological roles of alpha-B-crystallin and p53 expression in patients with head and neck squamous cell carcinoma. 18604737

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 AlteredExpression LHGDN p53 Codon 72 polymorphism and the risk of esophageal squamous cell carcinoma. 17918207

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 AlteredExpression LHGDN Immunoreactivity of p53 was found in 27% of SCC cases, but it had no significant relationship with SCC staging (p = 0.791). 18561741

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 AlteredExpression LHGDN The expression of p53-induced protein with death domain (Pidd) and apoptosis in oral squamous cell carcinoma. 17437012

2007

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation LHGDN p53 Codon 72 polymorphism, loss of heterozygosity and high-risk human papillomavirus infection in a low-incidence German esophageal squamous cell carcinoma patient cohort. 17390072

2007

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation LHGDN NF-kappaB gene signatures and p53 mutations in head and neck squamous cell carcinoma. 17908953

2007

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 AlteredExpression LHGDN Immunological characterization of missense mutations occurring within cytotoxic T cell-defined p53 epitopes in HLA-A*0201+ squamous cell carcinomas of the head and neck. 17294448

2007

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 Biomarker LHGDN Expression of p53 and its homolog, p73, in HPV DNA positive oesophageal squamous cell carcinomas. 17761206

2007

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation LHGDN P53 gene mutations in surgical margins and primary tumor tissues of patients with squamous cell carcinoma of the head and neck. 17557566

2007

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 AlteredExpression LHGDN The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1. 17198740

2007

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 AlteredExpression LHGDN Interplay between human papilloma virus infection and p53 gene alterations in head and neck squamous cell carcinoma of an Indian patient population. 17079356

2007

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 GeneticVariation LHGDN Dependency of repair of radiation-induced damage on p53 status and efficient inhibition of the repair with wortmannin treatment in vivo, with reference to the effect on intratumor quiescent cell population. 17982649

2007

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.600 Biomarker LHGDN Deletions of N33, STK11 and TP53 are involved in the development of lymph node metastasis in larynx and pharynx carcinomas. 17641416

2007