Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 AlteredExpression LHGDN Cyclooxygenase-2 expression is an independent predictor of poor prognosis in colon cancer. 19088039

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 Biomarker LHGDN Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells. 18326857

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 AlteredExpression LHGDN Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes. 17128412

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 Biomarker LHGDN RhoA mediates cyclooxygenase-2 signaling to disrupt the formation of adherens junctions and increase cell motility. 17178865

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 Biomarker LHGDN The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer. 16203768

2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 AlteredExpression LHGDN Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways. 15896711

2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 AlteredExpression LHGDN Marked increased expression of cyclooxygenase 2 (COX-2), a prostaglandin-synthesizing enzyme that is pharmacologically inhibited by nonsteroid anti-inflammatory-type drugs, is a major early oncogenic event in the genesis of human colon neoplasia. 15574495

2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 AlteredExpression LHGDN Cyclooxygenase-2 is up-regulated by interleukin-1 beta in human colorectal cancer cells via multiple signaling pathways. 12839952

2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 AlteredExpression LHGDN Orthotopic implantation of a colon cancer xenograft induces high expression of cyclooxygenase-2. 12767532

2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 Biomarker LHGDN Induction of cyclooxygenase-2 in monocyte/macrophage by mucins secreted from colon cancer cells. 12598658

2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 AlteredExpression LHGDN Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a. 14675489

2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 Biomarker LHGDN Inhibitory effect of a selective cyclooxygenase-2 inhibitor on liver metastasis of colon cancer. 12124799

2002
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 AlteredExpression LHGDN Nitric oxide, prostanoids, cyclooxygenase, and angiogenesis in colon and breast cancer. 11705852

2001