Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 Biomarker LHGDN Blocking of p53-Snail binding, promoted by oncogenic K-Ras, recovers p53 expression and function. 19107228

2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 Biomarker LHGDN Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway. 19020765

2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 Biomarker LHGDN Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: the roles of caspase-6 and p53. 18497562

2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 Biomarker LHGDN Synthetic lethality by lentiviral short hairpin RNA silencing of thymidylate kinase and doxorubicin in colon cancer cells regardless of the p53 status. 18413751

2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 Biomarker LHGDN Studies on p53, BAX and Bcl-2 protein expression and microsatellite instability in stage III (UICC) colon cancer treated by adjuvant chemotherapy: major prognostic impact of proapoptotic BAX. 17426704

2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 AlteredExpression LHGDN Regulation of p53 expression in response to 5-fluorouracil in human cancer RKO cells. 17634554

2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 Biomarker LHGDN Transcriptional activation of the carboxylesterase 2 gene by the p53 pathway. 16963839

2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 GeneticVariation LHGDN Polymorphisms in insulin-related genes predispose to specific KRAS2 and TP53 mutations in colon cancer. 16448675

2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 GeneticVariation LHGDN Evaluation of p53 codon 72 polymorphism in adenocarcinomas of the colon and rectum in La Plata, Argentina. 16552814

2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 Biomarker LHGDN PKCdelta requires p53 for suppression of the transformed phenotype in human colon cancer cells. 15601585

2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 AlteredExpression LHGDN p21(Waf1/Cip1) and p53 are downstream effectors of protein kinase C delta in tumor suppression and differentiation in human colon cancer cells. 15386430

2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 AlteredExpression LHGDN Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and -independent pathways. 15262986

2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 AlteredExpression LHGDN p53 gene mutations are rare in human papillomavirus-associated colon cancer. 14534749

2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 GeneticVariation LHGDN Genotyping of p53 codon 175 in colorectal cancer. 12761448

2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 Biomarker LHGDN Inhibition of COX-2 in colon cancer cell lines by celecoxib increases the nuclear localization of active p53. 14500353

2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 AlteredExpression LHGDN Neoangiogenesis in colon cancer: correlation between vascular density, vascular endothelial growth factor (VEGF) and p53 protein expression. 11956638

2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 GeneticVariation LHGDN Prognostic significance of p53 mutations in colon cancer at the population level. 11992552

2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.500 PosttranslationalModification LHGDN SN2 DNA-alkylating agent-induced phosphorylation of p53 and activation of p21 gene expression. 11890931

2002