Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.400 Biomarker LHGDN Three new nonsense mutations of MLH1 and MSH2 genes in Korean families with hereditary nonpolyposis colorectal cancer. 19100506

2009

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.400 GeneticVariation LHGDN Reduced mRNA expression in paraffin-embedded tissue identifies MLH1- and MSH2-deficient colorectal tumours and potential mutation carriers. 18581137

2008

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.400 AlteredExpression LHGDN Sporadic colon cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects. 18299982

2008

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.400 GeneticVariation LHGDN MSH2 missense mutations and HNPCC syndrome: pathogenicity assessment in a human expression system. 18781619

2008

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.400 Biomarker LHGDN Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer. 18949393

2008

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.400 GeneticVariation LHGDN Germline MLH1 and MSH2 mutational spectrum including frequent large genomic aberrations in Hungarian hereditary non-polyposis colorectal cancer families: implications for genetic testing. 17569143

2007

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.400 AlteredExpression LHGDN Novel hMSH2, hMSH6 and hMLH1 gene mutations and microsatellite instability in sporadic colorectal cancer. 16902769

2007

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.400 GeneticVariation LHGDN High proportion of large genomic rearrangements in hMSH2 in hereditary nonpolyposis colorectal cancer (HNPCC) families of the Basque Country. 17582678

2007

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.400 GeneticVariation LHGDN A novel MSH2 mutation in a Chinese family with hereditary non-polyposis colorectal cancer. 17333219

2007

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.400 Biomarker LHGDN Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling: Influence of smoking. 16874859

2006

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.400 Biomarker LHGDN Loss of protein expression of hMLH1 and hMSH2 with double primary carcinomas of the stomach and colorectum. 16786121

2006

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.400 AlteredExpression LHGDN Immunohistochemistry detects mismatch repair gene defects in colorectal cancer. 16684085

2006

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.400 GeneticVariation LHGDN Clinical and molecular characteristics of hereditary non-polyposis colorectal cancer families in Southeast Asia. 15996210

2005

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.400 AlteredExpression LHGDN The role of MLH1, MSH2 and MSH6 in the development of multiple colorectal cancers. 16106253

2005

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.400 AlteredExpression LHGDN Correlation between hMLH1/hMSH2 and p53 protein expression in sporadic colorectal cancer. 15816455

2005

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.400 Biomarker LHGDN The 5' region of the MSH2 gene involved in hereditary non-polyposis colorectal cancer contains a high density of recombinogenic sequences. 16086322

2005

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.400 GeneticVariation LHGDN Oncogenic pathway of sporadic colorectal cancer with novel germline missense mutations in the hMSH2 gene. 12792735

2004

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.400 GeneticVariation LHGDN Microsatellite instability (MSI) occurs from the mutational inactivation of the DNA mismatch repair genes, i.e. hMSH2 and hMLH1 in HNPCC, as well as from epigenetic inactivation of hMLH1 in sporadic colorectal tumors. 12808326

2003

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.400 Biomarker LHGDN A636P is associated with early-onset colon cancer in Ashkenazi Jews. 12595050

2003

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.400 GeneticVariation LHGDN Mutational analysis of promoters of mismatch repair genes hMSH2 and hMLH1 in hereditary nonpolyposis colorectal cancer and early onset colorectal cancer patients: identification of three novel germ-line mutations in promoter of the hMSH2 gene. 11782355

2002