Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma 		0.700 AlteredExpression LHGDN The ARF4L transcript preferentially localized to the polysomal compartment after PTEN loss in glioma or activation of Akt in human astrocytes. 18240926

2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma 		0.700 AlteredExpression LHGDN Protein expression of platelet-derived growth factor receptor correlates with malignant histology and PTEN with survival in childhood gliomas. 18519768

2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma 		0.700 PosttranslationalModification LHGDN We conclude that methylation of the PTEN promoter may represent an alternate mechanism by which PI3K signaling is increased in grade II and III gliomas as well as secondary GBMs, a finding that offers new therapeutic approaches in these patients. 17504928

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma 		0.700 AlteredExpression LHGDN PTEN down regulates AP-1 and targets c-fos in human glioma cells via PI3-kinase/Akt pathway. 17235455

2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma 		0.700 GeneticVariation LHGDN Rarity of PTEN deletions and EGFR amplification in malignant gliomas of childhood: results from the Children's Cancer Group 945 cohort. 17328268

2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma 		0.700 AlteredExpression LHGDN PTEN gene expression was suppressed in the glioma, which is related to the clinical-pathological results. 17000554

2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma 		0.700 GeneticVariation LHGDN Malignant glioma: the involvement of loss of allelic heterozygosity and PTEN mutations in a group of Malay patients. 16124450

2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma 		0.700 AlteredExpression LHGDN Regulation of c-Met-dependent gene expression by PTEN. 15516982

2004
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0017638
Disease: Glioma
Glioma 		0.700 GeneticVariation LHGDN Since then, important progress has been made with respect to the understanding of the role of the Pten protein in the normal development of the brain as well as in the molecular pathogenesis of human gliomas. 12084351

2002