Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 PosttranslationalModification LHGDN These results show a clear link between the epigenetic regulation through repression of HSD11B2 in PBMC DNA and hypertension. 18178212

2008
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 GeneticVariation LHGDN In AME, defective HSD11B2 enzyme activity results in overstimulation of the mineralocorticoid receptor (MR) by cortisol, causing sodium retention, hypokalemia, and salt-dependent hypertension. 16778331

2006
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 AlteredExpression LHGDN Variable activity of 11 beta HSD2 is relevant for blood pressure control and hypertension. 15489962

2004
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 AlteredExpression LHGDN Impaired 11-beta hydroxysteroid dehydrogenase type 2 activity in sweat gland ducts in human essential hypertension. 14981055

2004
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 Biomarker LHGDN The decreased activity of 11beta-HSD2 increases the intracellular availability of cortisol, which might be relevant for the pathogenesis of hypertension and preeclampsia. 12911547

2003