Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0023418
Disease: leukemia
leukemia
0.100 AlteredExpression LHGDN FLT3 mutations in a 10 year consecutive series of 177 childhood acute leukemias and their impact on global gene expression patterns. 17943971

2008

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0023418
Disease: leukemia
leukemia
0.100 AlteredExpression LHGDN Surface expression of FLT3 protein was correlated with high percentage of bone marrow blasts and with FLT3 mRNA expression (r=0.366, P<0.001) in acute leukemia. 18925699

2008

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation LHGDN In order to further analyze this phenomenon, we investigated the localization of FLT3, a subclass III receptor tyrosine kinase frequently mutated in leukemia. 18303245

2008

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation LHGDN Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles. 18068628

2007

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation LHGDN FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia. 17936561

2007

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation LHGDN Our data suggest that the FLT3 D324N variant might be associated with a predisposition to different subtypes of leukemia. 16320249

2006

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation LHGDN Taken together, these experiments establish that the FLT3/ITD mutations are present in leukemia stem cells, and that FLT3 inhibitors may have activity against these cells. 15797998

2005

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation LHGDN Therefore, FLT3 is a therapeutic target and inhibition of FLT3 tyrosine kinase activity may provide a new approach in the treatment of leukemia carrying these mutations. 16263569

2005

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0023418
Disease: leukemia
leukemia
0.100 AlteredExpression LHGDN An improved understanding of how FLT-3 interacts with its ligand, as well as how FLT-3 activating mutations are able to trigger downstream intracellular signaling pathways, will provide greater insight to how small molecule inhibitors may best be utilized and combined with established chemotherapeutic drugs for the management of patients with high-risk acute leukemia. 15778081

2005

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation LHGDN Activating FLT3 mutations in CD4+/CD8- pediatric T-cell acute lymphoblastic leukemias. 16326981

2005

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation LHGDN These data suggest that activating mutations of Flt3 may disrupt transcriptional repressor function resulting in aberrant gene regulation and abnormal leukemia cell growth. 14982881

2004

Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation LHGDN Normal and oncogenic FLT3. 15583855

2004