Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation LHGDN Among 18 BCR-ABL+ leukemias presenting acquired trisomy of chromosome 21, we report a high frequency (33%) of recurrent point mutations (4 in myeloid blast crisis [BC] CML and one in chronic phase CML) within the DNA-binding region of RUNX1. 18202228

2008

Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
CUI: C0023418
Disease: leukemia
leukemia
0.100 AlteredExpression LHGDN The increased expression of p21/WAF/Cip1 in primary leukemic blasts suggests that elevated p21/WAF/Cip1 levels may contribute to specific features observed in AML1-ETO positive leukemia. 18790797

2008

Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation LHGDN Combined high-resolution array-based comparative genomic hybridization and expression profiling of ETV6/RUNX1-positive acute lymphoblastic leukemias reveal a high incidence of cryptic Xq duplications and identify several putative target genes within the commonly gained region. 17690704

2007

Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
CUI: C0023418
Disease: leukemia
leukemia
0.100 AlteredExpression LHGDN We compared the leukemia cell gene expression profiles of 16 TEL/AML1-positive ALL patients to those of 44 TEL/AML1-negative patients, whose blast cells did not contain any additional recurrent translocation. 17956600

2007

Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
CUI: C0023418
Disease: leukemia
leukemia
0.100 AlteredExpression LHGDN The TEL-AML1 transgenic zebrafish models human pre-B ALL, identifies the molecular pathways associated with leukemia development, and serves as the foundation for subsequent genetic screens to identify modifiers and leukemia therapeutic targets. 17015828

2006

Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
CUI: C0023418
Disease: leukemia
leukemia
0.100 AlteredExpression LHGDN CpG island methylator phenotype redefines the prognostic effect of t(12;21) in childhood acute lymphoblastic leukemia. 16914570

2006

Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
CUI: C0023418
Disease: leukemia
leukemia
0.100 AlteredExpression LHGDN Thus, our data indicate that physical interaction and synergy between GATA1 and RUNX1 are retained in DS-AMKL, although it is still possible that increased RUNX1 activity plays a role in the development of leukemia in DS. 16628190

2006

Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
CUI: C0023418
Disease: leukemia
leukemia
0.100 AlteredExpression LHGDN The combined overexpression of RUNX1 and NCAM during stress hematopoiesis in children with DS might be a key factor in the development of overt leukemia and/or in the growth advantage of the malignant GATA1s clone in ML- DS. 17043020

2006

Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
CUI: C0023418
Disease: leukemia
leukemia
0.100 Biomarker LHGDN ETV6/RUNX1 fusion at diagnosis and relapse: some prognostic indications. 15704129

2005

Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation LHGDN The fusion gene produces a chimeric transcription factor that suppresses the expression of AML1-target genes via the MTG8 part of the chimeric protein, which is thought to be the primary cause of leukemia. 15723339

2005

Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
CUI: C0023418
Disease: leukemia
leukemia
0.100 AlteredExpression LHGDN Amplification of AML1 in acute lymphoblastic leukemia is associated with a poor outcome. 14523475

2003

Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation LHGDN This is consistent with the hypothesis that a second mutation has to occur, either in RUNX1 or another gene, to cause leukemia among individuals harboring RUNX1 FPD/AML mutations and that the propensity to acquire these additional mutations is determined, at least partially, by the initial RUNX1 mutation. 11830488

2002

Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation LHGDN Runx1/AML1 association with its partners is disrupted in leukemia. 11792409

2002

Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation LHGDN [Analyses of the mutations of AML 1 gene in myelodysplastic syndromes]. 11979742

2002

Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
CUI: C0023418
Disease: leukemia
leukemia
0.100 AlteredExpression LHGDN AML1 stimulates G1 to S progression via its transactivation domain. 12082641

2002