Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7535
Gene Symbol: ZAP70
ZAP70
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 Biomarker LHGDN Although it is premature to recommend therapy based on these risk factors, patients with ZAP-70-positive CLL cells should be monitored closely for disease progression as they have a median time from diagnosis to requiring initial therapy by standard criteria of approximately 3 years. 18577710

2008

Entrez Id: 7535
Gene Symbol: ZAP70
ZAP70
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 AlteredExpression LHGDN These are used to index ZAP-70 protein expression levels in the CLL population. 18770856

2007

Entrez Id: 7535
Gene Symbol: ZAP70
ZAP70
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 GeneticVariation LHGDN These data point to the need for a more extensive study to evaluate the significance of Zap-70 and CD38 expression as indicators of IgVH mutation status and prognosis of CLL patients. 17931624

2007

Entrez Id: 7535
Gene Symbol: ZAP70
ZAP70
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 Biomarker LHGDN The simultaneous expression of ZAP-70 and CD38 in 157 patients with CLL has been evaluated. 17534928

2007

Entrez Id: 7535
Gene Symbol: ZAP70
ZAP70
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 Biomarker LHGDN Some new prognostic factors, such as immunoglobulin variable heavy chain (IgVH) mutational status, zeta-associated protein (ZAP-70) and CD38 expression in leukemic cells were introduced to identify attenuated versus progressive types of CLL bearing the potential to facilitate risk-adapted treatment strategies. 18689273

2006

Entrez Id: 7535
Gene Symbol: ZAP70
ZAP70
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 PosttranslationalModification LHGDN Measuring ZAP-70 methylation status at C-334 is a simple and reproducible method for predicting prognosis in CLL, which is closely associated with ZAP-70 expression and IgVH gene mutational status. 16079107

2005

Entrez Id: 7535
Gene Symbol: ZAP70
ZAP70
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 PosttranslationalModification LHGDN ZAP-70 methylation and expression status in chronic lymphocytic leukemia. 16079094

2005

Entrez Id: 7535
Gene Symbol: ZAP70
ZAP70
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 Biomarker LHGDN This unit focuses on protocols to quantify ZAP-70 by flow cytometry in CLL. 18770822

2005

Entrez Id: 7535
Gene Symbol: ZAP70
ZAP70
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 Biomarker LHGDN Additionally, ZAP-70 expression in CLL cells confers markedly heightened sensitivity to 17-AAG or 17-DMAG, suggesting that these or other Hsp90 inhibitors could be valuable therapeutically in patients with aggressive CLL. 15972449

2005

Entrez Id: 7535
Gene Symbol: ZAP70
ZAP70
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 Biomarker LHGDN The problems with ZAP-70 measurement, which has yet to be standardized, are reviewed together with its current status as a prognostic marker in CLL. 16263570

2005

Entrez Id: 7535
Gene Symbol: ZAP70
ZAP70
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 AlteredExpression LHGDN In particular, ZAP-70 is especially attractive because its aberrant expression in tumour cells from the more aggressive forms of CLL requires the chaperoning action of activated heat-shock protein 90, which may be specifically inhibited. 16300468

2005

Entrez Id: 7535
Gene Symbol: ZAP70
ZAP70
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 Biomarker LHGDN These data show the characterization and generation of a novel murine leukemia model with many similarities to human ZAP-70+ B cell chronic lymphocytic leukemia. 15856008

2005

Entrez Id: 7535
Gene Symbol: ZAP70
ZAP70
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.100 AlteredExpression LHGDN In 7 patients, ZAP-70 expression and IgVH mutation status were discordant: 4 Ig-mutated CLLs had high ZAP-70 expression and 3 Ig-unmutated CLLs had low ZAP-70 expression. 12595313

2003