Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1019
Gene Symbol: CDK4
CDK4
CUI: C0025202
Disease: melanoma
melanoma 		0.700 Biomarker LHGDN We suggest that co-overexpression of KIT/CDK4 is a potential mechanism of oncogenic transformation in some BRAF/NRAS wild-type melanomas. 18632627

2008
Entrez Id: 1019
Gene Symbol: CDK4
CDK4
CUI: C0025202
Disease: melanoma
melanoma 		0.700 GeneticVariation LHGDN Germline mutations of the CDKN2A gene are found in < 25% of melanoma-prone families and there are only seven families with mutation of the CDK4 gene reported to date. 18803811

2008
Entrez Id: 1019
Gene Symbol: CDK4
CDK4
CUI: C0025202
Disease: melanoma
melanoma 		0.700 GeneticVariation LHGDN Population-based prevalence of CDKN2A and CDK4 mutations in patients with multiple primary melanomas. 18023021

2008
Entrez Id: 1019
Gene Symbol: CDK4
CDK4
CUI: C0025202
Disease: melanoma
melanoma 		0.700 Biomarker LHGDN No disease-related CDKN2A germline mutations were identified in any of the melanoma patients analysed but the previously described CDK4 mutation, Arg24His, was found in one patient with a family history of melanoma. 17505264

2007
Entrez Id: 1019
Gene Symbol: CDK4
CDK4
CUI: C0025202
Disease: melanoma
melanoma 		0.700 GeneticVariation LHGDN The CDK4 mutation in the Norwegian family was identical to that in melanoma families in France, Australia, and England. 15880589

2005
Entrez Id: 1019
Gene Symbol: CDK4
CDK4
CUI: C0025202
Disease: melanoma
melanoma 		0.700 GeneticVariation LHGDN Thus the phenotype observed in melanoma-prone CDK4 families appears to be more complex than just the CDK4 mutation. 11828258

2002