Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4286
Gene Symbol: MITF
MITF
CUI: C0025202
Disease: melanoma
melanoma
0.700 AlteredExpression LHGDN Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor. 19188590

2009

Entrez Id: 4286
Gene Symbol: MITF
MITF
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker LHGDN MiTF-negative melanoma cells survived more poorly under ROS stress than the MiTF-positive cells based on 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and Trypan blue staining. 18971960

2009

Entrez Id: 4286
Gene Symbol: MITF
MITF
CUI: C0025202
Disease: melanoma
melanoma
0.700 AlteredExpression LHGDN Collectively, these findings implicate MITF as a major transcriptional regulator of ML-IAP expression in melanomas, and suggest that ML-IAP contributes to the prosurvival activity of MITF in melanoma progression. 18451137

2008

Entrez Id: 4286
Gene Symbol: MITF
MITF
CUI: C0025202
Disease: melanoma
melanoma
0.700 AlteredExpression LHGDN MicroRNA-137 targets microphthalmia-associated transcription factor in melanoma cell lines. 18316599

2008

Entrez Id: 4286
Gene Symbol: MITF
MITF
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker LHGDN Critically, in melanoma cells MITF is required downstream of oncogenic BRAF because it regulates expression of key cell cycle regulatory proteins such as CDK2 and CDK4. 18628967

2008

Entrez Id: 4286
Gene Symbol: MITF
MITF
CUI: C0025202
Disease: melanoma
melanoma
0.700 AlteredExpression LHGDN Our findings suggest that strong amplifications of the melanoma oncogene MITF affects patient survival but does not influence tumor chemosensitivity and chemotherapy response. 17975146

2007

Entrez Id: 4286
Gene Symbol: MITF
MITF
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker LHGDN By contrast, we show here that in melanomas invasiveness can be regulated epigenetically by the microphthalmia-associated transcription factor, Mitf, via regulation of the DIAPH1 gene encoding the diaphanous-related formin Dia1 that promotes actin polymerization and coordinates the actin cytoskeleton and microtubule networks at the cell periphery. 17182868

2006

Entrez Id: 4286
Gene Symbol: MITF
MITF
CUI: C0025202
Disease: melanoma
melanoma
0.700 AlteredExpression LHGDN Using an integrated analysis of high-resolution single nucleotide polymorphism maps and gene expression databases associated with the NCI60 collection cancer cell lines, we identified the transcription factor MITF as an amplified oncogene in melanoma that is critical for anchoring lineage dependence and malignant character. 16510564

2006

Entrez Id: 4286
Gene Symbol: MITF
MITF
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker LHGDN Microphthalmia transcription factor as a molecular marker for circulating tumor cell detection in blood of melanoma patients. 16489066

2006

Entrez Id: 4286
Gene Symbol: MITF
MITF
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker LHGDN We therefore conclude that the alpha-MSH/cAMP pathway, using MITF as a signal transducer and HIF1alpha as a target, might contribute to melanoma progression. 15983061

2005

Entrez Id: 4286
Gene Symbol: MITF
MITF
CUI: C0025202
Disease: melanoma
melanoma
0.700 AlteredExpression LHGDN These data suggest that MITF is an anti-proliferation factor that is down-regulated by B-RAF signaling and that this is a crucial event for the progression of melanomas that harbor oncogenic B-RAF. 16129781

2005

Entrez Id: 4286
Gene Symbol: MITF
MITF
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker LHGDN Moreover, suppression of melanoma clonogenic growth by disruption of beta-catenin-T-cell transcription factor/LEF is rescued by constitutive MITF. 12235125

2002

Entrez Id: 4286
Gene Symbol: MITF
MITF
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker LHGDN Clinically, primary human melanoma expression microarrays revealed tight nearest neighbor linkage for MITF and BCL2. 12086670

2002