Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker LHGDN The aims of this study was to compare the value of tyrosinase mRNA by reverse transcription polymerase chain reaction (RT-PCR) in peripheral blood and of serum S-100 protein in patients with melanoma at different stages of disease. 18845991

2008

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 GeneticVariation LHGDN The variant in TYR encoding the R402Q amino acid substitution, previously shown to affect eye color and tanning response, conferred risk of CM (OR = 1.21, P = 2.8 x 10(-7)) and BCC (OR = 1.14, P = 6.1 x 10(-4)). 18488027

2008

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 AlteredExpression LHGDN In DB-1 melanoma cells that overexpress tyrosinase (Tyr(+) cells), the threshold for phosphorylation of ATM and p53 at serine 15 was observed at a low dose of Qct (25 microM) when compared to the mock transfected pcDNA3 cells, which required a higher dose (75 microM). 18791269

2008

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker LHGDN A preliminary study in human blood samples demonstrated a baseline positive tyrosinase determination in 64% (16/25) of advanced melanoma patients using the RT-PCR nested assay. 18425346

2008

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker LHGDN Multimarker real-time reverse transcription-PCR for quantitative detection of melanoma-associated antigens: a novel possible staging method. 18181974

2008

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker LHGDN The clinical usefulness of tyrosinase in stage IV melanoma patients is still debated, owing to the wide range of variability (positive expression from 30 up to 100% of patients) and the possibility of a transient shedding of melanoma cells into the bloodstream. 17496782

2007

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker LHGDN From January 2000 to February 2003, duplicate blood samples were drawn from 114 melanoma patients following surgery and informed consent, and were tested with reverse transcriptase-PCR, for tyrosinase mRNA. 17496783

2007

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker LHGDN We report that the tyrosinase autoantigen was immunorecognized with the same molecular pattern by sera from vitiligo and melanoma patients. 16272362

2005

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker LHGDN Detection of multiple melanoma-associated markers in melanoma cell lines by RT in situ PCR. 12710945

2003

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker LHGDN Because it was previously shown that V-ATPase activity is increased in solid tumors in response to an acidified environment, the appearance of hypopigmented cells in tyrosinase-positive melanoma tumors may indicate the onset of enhanced glycolysis and extracellular acidification, conditions known to favor metastatic spread and resistance to weak base chemotherapeutic drugs. 11812790

2002