Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN Taken together, these results suggest that cellular PTPN13 inhibits Her2 activity by dephosphorylating the signal domain of Her2 and plays a role in attenuating invasiveness and metastasis of Her2 overactive tumors. 17982484

2008

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker LHGDN On brain metastasis progression, 18 (20%) of HER2+ patients received further local therapy compared with 6 (6%) in HER2- group. 18571923

2008

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN Despite matching for tumor size, grade 1 IDC have a higher incidence of lymph node metastasis and may have Her-2-neu overexpression compared to TC. 18801081

2008

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN HER2 overexpression (2+/3+) was found in only 3 of the primary ESCC tumours and 2 of the lymph node metastases. 17671674

2007

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker LHGDN In the extrahepatic cholangiocarcinomas, the expression of c-erbB-2 was directly proportional to the malignant grade and tumor metastasis. 17690040

2007

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN In subgroup with lymph node metastases who exhibit HER-2/neu overexpression might constitute potential candidates for new adjuvant therapy, such as humanized monoclonal antibodies. 17322545

2007

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN In conclusion, our results indicate that expression of c-erbB-2 and p53 did not have any prognostic value in patients with early-stage breast cancer in which axillary lymph node metastasis is absent. 17478762

2007

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN Either c-erbB-2 expression or COX-2 expression was significantly associated with lymph node metastasis (p=0.0442). 18159174

2007

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker LHGDN Clinical evaluation of the simultaneous determination of CA 15-3, CA 125 and sHER2 in breast cancer. 17852076

2007

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN This study suggested that 42.5% of patients with invasive bladder cancer may benefit from molecular-targeted therapy targeting HER-2, and that the efficacy of molecular-targeted therapy can be expected even for patients with lymph node metastases as long as their primary tumors are HER-2 positive. 17549338

2007

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN Also, the serum HER2 level was significantly higher in bone metastatic cancer patients (14.3 +/- 6.3 ng/mL) than in non-metastatic patients (T2: 11.9 +/- 2.3 ng/mL, P = 0.003; T3: 12.2 +/- 2.8 ng/mL, P = 0.011). 16984552

2006

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN The aim of this study was to explore the potential functional role of HER-2 in primary breast tumors with bone metastases. 16685382

2006

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker LHGDN The results indicate that the expression of EGFR, c-erbB-2, VEGF or MMPs play an important role in tumor growth, invasion and metastasis in HNSCC. 15254682

2004

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN Expression of nm 23 was observed in 66% and that of c-erbB2 in 59% of liver metastases. 14664140

2004

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN Immunohistological study of NM 23 and C-erbB-2 expression in primary tumor and metastases of colorectal adenocarcinoma. 12910292

2003

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression LHGDN In contrast, the positivity of c-erbB-2 staining in intrahepatic cholangiocarcinoma was significantly higher in cases with lymph node metastasis than in cases without. 11895493

2002

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker LHGDN NH(2)-terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer. 11839648

2002