Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression LHGDN The high expression of nuclear CXCR4 in hormone receptor negative breast cancer was associated with a high possibility of lymph node metastasis. 17763975

2008

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression LHGDN Statistical analyses of the association between presence of lymph node metastases and CXCR4 expression levels revealed that cytoplasmic CXCR4 expression was not associated with the presence of lymph node metastases. 18701133

2008

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker LHGDN Our study provides strong evidence for the involvement of the bone marrow microenvironment and CXCR4/SDF1alpha signaling in metastasis of RMS. 17768666

2008

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker LHGDN However, CXCR4 and CCR7 expression was sharply reduced in liver metastases arising from intraocular melanomas. 18235009

2008

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression LHGDN In conclusion, expression of SDF-1 alpha and nuclear CXCR4 predicts LN metastasis in CRCs. 18443596

2008

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression LHGDN We next examined whether SDF-1alpha played roles in EOC progression, including in proliferation, cell motility, attachment to HPMCs, and the in vivo development of peritoneal metastasis through CXCR4. 17893878

2008

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression LHGDN However, CXCR4 mRNA was higher in the distant metastasis group than in the non-distant metastasis group (P=0.032). 18502034

2008

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression LHGDN High-intensity IHC staining for CXCR4 was associated with larger tumor size (P = .02), while PTCs exhibiting ETE, ALI, or lymph node metastasis showed higher-intensity IHC staining for CCR7 than those without (P = .01, .03, and .01, respectively). 18696160

2008

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression LHGDN CXCR4 and CCR7 expression may be associated with lymph node metastasis; moreover, the expression of these receptors can serve as an indicator of poor prognosis in patients with cervical cancer. 17032700

2007

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 GeneticVariation LHGDN We propose that p53 rescue drugs either alone or in combination with chemotherapeutic drugs may be effective in reducing CXCR4-mediated metastasis. 17130833

2007

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression LHGDN These data support the conclusion that miRNA against CXCR4 can serve as an alterative means of therapy to lower CXCR4 expression and to block the invasion and metastasis of breast cancer cells. 17889832

2007

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression LHGDN Here we showed that (a) CXCL12/CXCR4 axis is expressed in PC bone metastasis; (b) exogenous CXCL12 induced MMP-9 expression by PC cells; (c) bone stromal cells and bone tissue conditioned media induced the migration of PC cells in a CXCR4-dependent manner; (d) pharmacological inhibition of PI3 kinase and MAP kinase pathways abrogated CXCL12-induced MMP-9 expression and invasion of PC cells; (e) exogenous CXCL12 induced Akt1 phosphorylation is indispensable for proMMP-9 secretion, migration, and invasion of PC cells; (f) CXCR4 was localized to lipid rafts in PC cells and initiated Akt phosphorylation. 16114056

2006

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression LHGDN CXCR4 expression was detected in 33 out of 63 (52.4%) metastases from cutaneous melanomas. 16638848

2006

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression LHGDN Here we show that: (1) hypoxia is an important factor in regulating CXCR4 mediated metastasis and the cells exhibited reducing invasion, adhesion and migration in response to CXCL12 after knocking down HIF. 16929169

2006

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker LHGDN Regarding the correlation between nodal metastasis and the expression of CXCR4 and VEGF-C, the incidence of nodal metastasis was significantly (p < 0.01) higher in patients with CXCR4-positive tumors than in those with CXCR4-negative tumors. 17641542

2006

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker LHGDN Collectively, these findings suggest that CXCR4 might be involved in the lymph-node metastasis of OSCC. 16327980

2006

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression LHGDN Chemokine expression in hepatocellular carcinoma versus colorectal liver metastases. 17075975

2006

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression LHGDN CXCR4, but not CCR7, expression dramatically increased the in vivo metastatic potential of TD-2 cells, resulting in liver and lung metastasis in nude mice. 16230077

2005

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker LHGDN These properties identify CXCR4 as a potential target for the attenuation of bladder cancer metastases. 15540205

2005

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker LHGDN Here, we show that HER2 enhances the expression of CXCR4, which is required for HER2-mediated invasion in vitro and lung metastasis in vivo. 15542430

2004

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker LHGDN Although we were unable to find a statistically significant association between the expression of SDF-1 and any clinicopathological factors, we did find a significant association between the expression of CXCR4 and lymph node metastasis (P=0.0417). 15201990

2004

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 Biomarker LHGDN It has also been proposed that the stromal cell-derived factor-1 (SDF-1; CXCL12)/CXCR4 system might be involved lymph node metastasis in oral squamous cell carcinoma (SCC). 15492752

2004

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression LHGDN CXCR4 expression in metastatic cancer tissue was significantly higher than that in nonmetastatic cancer tissue or normal gingiva. 14567988

2003

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.400 AlteredExpression LHGDN Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. 11912162

2002