×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
GeneticVariation
LHGDN
JAK2 V617F/C618R mutation in a patient with polycythemia vera: a case study and review of the literature.
19167611
2009
×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
GeneticVariation
LHGDN
"The significance of bone marrow biopsy and JAK2V617F mutation in the differential diagnosis between the ""early"" prepolycythemic phase of polycythemia vera and essential thrombocythemia."
18701405
2008
×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
Biomarker
LHGDN
Long-term bone marrow cultures (LTBMC) from essential thrombocythemia (ET) patients with or without JAK2617V>F mutation.
18321571
2008
×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
AlteredExpression
LHGDN
Rapid decline of JAK2V617F levels during hydroxyurea treatment in patients with polycythemia vera and essential thrombocythemia.
18519514
2008
×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
GeneticVariation
LHGDN
JAK2 and MPL mutations in myeloproliferative neoplasms: discovery and science.
18754026
2008
×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
GeneticVariation
LHGDN
Frequent reduction or absence of detection of the JAK2-mutated clone in JAK2V617F-positive patients within the first years of hydroxyurea therapy.
18728027
2008
×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
GeneticVariation
LHGDN
Furthermore, CP-690,550 treatment of ex-vivo-expanded erythroid progenitors from JAK2 (V617F )-positive PV patients resulted in specific, antiproliferative (IC(50) = 0.2 microM) and pro-apoptotic activity.
18482053
2008
×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
GeneticVariation
LHGDN
JAK2 and MPL mutations in myeloproliferative neoplasms.
18566540
2008
×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
GeneticVariation
LHGDN
Finally, a significant correlation between JAK2 V617F mutational status and hematocrit (Ht), white blood cell and platelet counts in PV patients, and Ht values in ET cases, was observed by AS-PCR.
18720212
2008
×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
GeneticVariation
LHGDN
JAK2 Mutations are present in all cases of polycythemia vera.
18079740
2008
×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
GeneticVariation
LHGDN
Behavioral, biochemical, and genetic analysis of iron metabolism in high-intensity blood donors.
18657084
2008
×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
GeneticVariation
LHGDN
Clonal heterogeneity in polycythemia vera patients with JAK2 exon12 and JAK2 -V617F mutations.
18195094
2008
×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
GeneticVariation
LHGDN
Quantitative assessment of the JAK2 V617F allele burden: equivalent levels in peripheral blood and bone marrow.
17625603
2008
×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
GeneticVariation
LHGDN
Cytogenetic studies at diagnosis in polycythemia vera: clinical and JAK2V617F allele burden correlates.
18081705
2008
×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
GeneticVariation
LHGDN
We conclude that a burden of JAK2 (V617F) allele greater than 75% at diagnosis points to PV patients with high-risk disease.
17625606
2007
×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
GeneticVariation
LHGDN
The JAK2 617V>F mutation triggers erythropoietin hypersensitivity and terminal erythroid amplification in primary cells from patients with polycythemia vera.
17389763
2007
×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
GeneticVariation
LHGDN
Cellular origin and lineage specificity of the JAK2(V617F) allele in polycythemia vera.
17190855
2007
×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
GeneticVariation
LHGDN
Usefulness of JAK2V617F mutation in distinguishing idiopathic erythrocytosis from polycythemia vera.
16620973
2007
×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
GeneticVariation
LHGDN
JAK2 exon 12 mutations in polycythemia vera or idiopathic erythrocytosis.
18056003
2007
×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
GeneticVariation
LHGDN
Prevalence and clinicopathologic correlates of JAK2 exon 12 mutations in JAK2V617F-negative polycythemia vera.
17597810
2007
×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
GeneticVariation
LHGDN
JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis.
17267906
2007
×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
GeneticVariation
LHGDN
Bone marrow renin-angiotensin system expression in polycythemia vera and essential thrombocythemia depends on JAK2 mutational status.
17873518
2007
×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
GeneticVariation
LHGDN
Bone marrow JAK2V617F allele burden and clinical correlates in polycythemia vera.
17476276
2007
×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
GeneticVariation
LHGDN
Analysis of JAK2(V617F) mutation in Chinese patients with myeloproliferative disorders.
17266061
2007
×
Entrez Id:
3717
Gene Symbol:
JAK2
JAK2
Polycythemia Vera
1.000
Biomarker
LHGDN
Clinical profile of homozygous JAK2 617V>F mutation in patients with polycythemia vera or essential thrombocythemia.
17379742
2007