Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 GeneticVariation LHGDN Association of reported prostate cancer risk alleles with PSA levels among men without a diagnosis of prostate cancer. 19116992

2009

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 AlteredExpression LHGDN Suppression of androgen receptor signaling and prostate specific antigen expression by (-)-epigallocatechin-3-gallate in different progression stages of LNCaP prostate cancer cells. 18977589

2009

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker LHGDN Evaluation of molecular forms of prostate-specific antigen and human kallikrein 2 in predicting biochemical failure after radical prostatectomy. 19003994

2009

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker LHGDN Transrectal ultrasound and prostate-specific antigen in prostate cancer. 19032406

2008

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker LHGDN Prostate-specific membrane antigen associates with anaphase-promoting complex and induces chromosomal instability. 18645024

2008

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 AlteredExpression LHGDN Ubiquitylation of epsilon-COP by PIRH2 and regulation of the secretion of PSA. 17721809

2008

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 GeneticVariation LHGDN PSA and androgen-related gene (AR, CYP17, and CYP19) polymorphisms and the risk of adenocarcinoma at prostate biopsy. 18491956

2008

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker LHGDN Establishment of CXCR4-small interfering RNA retrovirus vector driven by human prostate-specific antigen promoter and its biological effects on prostate cancer in vitro and in vivo. 18431597

2008

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 AlteredExpression LHGDN The use of prostate specific antigen (PSA) density in detecting prostate cancer in Chinese men with PSA levels of 4-10 ng/mL. 18446367

2008

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 GeneticVariation LHGDN Novel splice variants of prostate-specific antigen and applications in diagnosis of prostate cancer. 18222179

2008

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 GeneticVariation LHGDN Prostate-specific antigen and 17-hydroxylase polymorphic genotypes in patients with prostate cancer and benign prostatic hyperplasia. 17961073

2007

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 GeneticVariation LHGDN Is there an inter-relationship between prostate specific antigen, kallikrein-2 and androgen receptor gene polymorphisms with risk of prostate cancer in north Indian population? 17257635

2007

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker LHGDN Prostate cancer mortality in relation to screening by prostate-specific antigen testing and digital rectal examination: a population-based study in middle-aged men. 17641982

2007

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 GeneticVariation LHGDN Tagging SNPs in the kallikrein genes 3 and 2 on 19q13 and their associations with prostate cancer in men of European origin. 17593395

2007

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 GeneticVariation LHGDN PSA/KLK3 AREI promoter polymorphism alters androgen receptor binding and is associated with prostate cancer susceptibility. 17151093

2007

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 AlteredExpression LHGDN Regulation of prostate cancer cell growth and PSA expression by angiotensin II receptor blocker with peroxisome proliferator-activated receptor gamma ligand like action. 17440964

2007

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker LHGDN Usefulness of prostate-specific antigen nadir as predictor of androgen-independent progression of metastatic prostate cancer. 16398402

2006

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker LHGDN Correlation between serum prostate-specific antigen and alpha-1-antitrypsin in men without and with prostate cancer. 16581345

2006

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker LHGDN Overexpression of CXCL10 in human prostate LNCaP cells activates its receptor (CXCR3) expression and inhibits cell proliferation. 16934957

2006

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 GeneticVariation LHGDN Association of vitamin D receptor FokI polymorphism with prostate cancer risk, clinicopathological features and recurrence of prostate specific antigen after radical prostatectomy. 16708371

2006

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker LHGDN Free/Total PSA (F/T ratio) kinetics in patients with clinically localized prostate cancer undergoing radical prostatectomy. 15936010

2005

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker LHGDN Kallikrein 4 (hK4) and prostate-specific antigen (PSA) are associated with the loss of E-cadherin and an epithelial-mesenchymal transition (EMT)-like effect in prostate cancer cells. 16172196

2005

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker LHGDN Serenoa repens (Permixon) inhibits the 5alpha-reductase activity of human prostate cancer cell lines without interfering with PSA expression. 15543614

2005

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 Biomarker LHGDN Prostate cancer and prostate-specific antigen (PSA) screening in Austria. 16091872

2005

Entrez Id: 354
Gene Symbol: KLK3
KLK3
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.400 AlteredExpression LHGDN Preferential production of latent transforming growth factor beta-2 by primary prostatic epithelial cells and its activation by prostate-specific antigen. 15389580

2005