Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 GeneticVariation LHGDN Our results indicate that the three functional DRD2 variants modulate schizophrenia phenotypes possibly by modifying D2S/D2L ratios in the context of different total D2 density. 18829695

2009

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 Biomarker LHGDN Dose-occupancy study of striatal and extrastriatal dopamine D2 receptors by aripiprazole in schizophrenia with PET and [18F]fallypride. 18418366

2008

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 GeneticVariation LHGDN Association study of three polymorphisms in the dopamine D2 receptor gene and schizophrenia in the Russian population. 18255274

2008

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 Biomarker LHGDN Possible involvement of post-dopamine D2 receptor signalling components in the pathophysiology of schizophrenia. 17681085

2008

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 GeneticVariation LHGDN The -141C Del allele, which produces lower expression of DRD2, may protect against dopaminergic hyperactivity in schizophrenia. 18496209

2008

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 GeneticVariation LHGDN These data suggest that the DRD2 A-241G polymorphism or, alternatively, another genetic variation that is in linkage disequilibrium, may influence response to risperidone in schizophrenia patients. 17105675

2007

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 GeneticVariation LHGDN Support for an association of the C939T polymorphism in the human DRD2 gene with tardive dyskinesia in schizophrenia. 17669630

2007

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 GeneticVariation LHGDN The strong association between a potentially functional polymorphism, downstream of the DRD2 gene and schizophrenia, suggests that the direct or indirect functional effects of this polymorphism, acting on either the ANKK1 or DRD2 genes, may play a role in the pathophysiology of schizophrenia. 17417059

2007

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 AlteredExpression LHGDN These data are consistent with clinical evidence that only dopamine D(2) receptor partial agonists with a sufficiently low enough intrinsic activity will prove effective against the positive symptoms of schizophrenia, and also highlight the importance of using downstream-based assays in the discovery of novel D(2) receptor partial agonist therapeutics. 17092971

2007

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 Biomarker LHGDN We propose that an interaction of the DRD2 C957T and COMT Val158Met may be involved in the generation of some working memory deficits in schizophrenia. 17113268

2007

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 GeneticVariation LHGDN Dopamine D2 receptor gene polymorphisms predict well the response to dopamine antagonists at therapeutic dosages in patients with schizophrenia. 17362435

2007

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 Biomarker LHGDN The human dopamine receptor D2 (DRD2) gene is associated with tardive dyskinesia in patients with schizophrenia. 16769201

2006

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 GeneticVariation LHGDN This study investigates the association of synonymous polymorphisms (His313 and Pro319) in the dopamine D2 receptor gene with schizophrenia using a case-control approach, with 101 cases and 145 controls. 16183199

2006

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 Biomarker LHGDN Our results are in agreement with an earlier association study suggesting that the C957T C-allele plays a role in the genetic vulnerability for schizophrenia and support the involvement of the DRD2 gene in schizophrenia pathogenesis. 16973280

2006

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 GeneticVariation LHGDN [Association of schizophrenia with a promoter polymorphism in the dopamine D2 receptor gene]. 15696493

2005

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 GeneticVariation LHGDN We tested for an association between polydipsia in schizophrenia and three functional polymorphisms of DRD2. 15850500

2005

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 GeneticVariation LHGDN Recent meta-analyses confirmed a small but reliable association between schizophrenia and the cysteine-coding allele of the Cys311Ser polymorphism of DRD2. 15211624

2004

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 GeneticVariation LHGDN [No association of 141C-ins/del polymorphism in the D2 dopamine receptor gene in schizophrenia]. 14509080

2003

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 Biomarker LHGDN Gender-specific molecular heterosis of dopamine D2 receptor gene (DRD2) for smoking in schizophrenia. 12210271

2002

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 GeneticVariation LHGDN A functional polymorphism in the promoter region of the DRD2 gene has been found to be associated with schizophrenia in Japanese(1,2) and Swedish populations. 12399954

2002