Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1814
Gene Symbol: DRD3
DRD3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Here, we confirmed the existence of a common protective haplotype against schizophrenia at the dopamine D(3) receptor (DRD3) gene, by replication and pooled analysis with previous data (Mantel-Haenszel chi(2) P value = 0.00227; OR = 0.79, 95% CI 0.68-0.92, based on 794 cases and 1,078 controls from three independent populations of European origin). 18987889

2009

Entrez Id: 1814
Gene Symbol: DRD3
DRD3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN A network of dopaminergic gene variations implicated as risk factors for schizophrenia. 18045777

2008

Entrez Id: 1814
Gene Symbol: DRD3
DRD3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Our study does not support the contention that the Ser9Gly polymorphism of the DRD3 gene plays a major role in schizophrenia in the Chinese population. 18295456

2008

Entrez Id: 1814
Gene Symbol: DRD3
DRD3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN One polymorphism at DRD2 gene, five at DRD3, 24 at CYP2D6, nine at CYP3A4 gene, and one at CYP3A5 gene were genotyped in a sample of 186 patients with schizophrenia. 18551040

2008

Entrez Id: 1814
Gene Symbol: DRD3
DRD3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker LHGDN Could HTR2A T102C and DRD3 Ser9Gly predict clinical improvement in patients with acutely exacerbated schizophrenia? Results from treatment responses to risperidone in a naturalistic setting. 17924589

2008

Entrez Id: 1814
Gene Symbol: DRD3
DRD3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Effects of the dopamine D3 receptor (DRD3) gene polymorphisms on risperidone response: a pharmacogenetic study. 17429404

2008

Entrez Id: 1814
Gene Symbol: DRD3
DRD3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Multiple variants of the DRD3, but not BDNF gene, influence age-at-onset of schizophrenia. 18043709

2007

Entrez Id: 1814
Gene Symbol: DRD3
DRD3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN These results suggest that the DRD3 variant containing glycine is associated with more efficient striatal habit learning in healthy controls and patients with schizophrenia. 15998189

2005

Entrez Id: 1814
Gene Symbol: DRD3
DRD3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Age at onset of schizophrenia: interaction between brain-derived neurotrophic factor and dopamine D3 receptor gene variants. 16056149

2005

Entrez Id: 1814
Gene Symbol: DRD3
DRD3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 AlteredExpression LHGDN The aim of this study was to test the hypothesis of elevated DRD3 mRNA in schizophrenia compared to bipolar disorder. 15539862

2004

Entrez Id: 1814
Gene Symbol: DRD3
DRD3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Chinese Han patients with schizophrenia were assessed for abnormal involuntary movements, and subgroups of 42 patients with persistent tardive dyskinesia and 59 consistently without dyskinesias were assessed for the DRD3 ser9gly and the MnSOD ala-9val polymorphisms. 12960753

2003

Entrez Id: 1814
Gene Symbol: DRD3
DRD3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Whereas the present Swedish case-control analysis did not yield any evidence for association with the diagnosis, the present meta-analysis suggests that the DRD3 gene confer susceptibility to schizophrenia. 12605094

2003

Entrez Id: 1814
Gene Symbol: DRD3
DRD3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN We conclude that PDYN gene polymorphism alone does not alter the risk for schizophrenia but, by an epistatic interaction with the Gly allele of DRD3 gene, may contribute to the susceptibility to this disorder. 12207142

2002

Entrez Id: 1814
Gene Symbol: DRD3
DRD3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN The results from this study imply that neither the coding nor the regulatory region of DRD3 plays a major role in predisposition to schizophrenia. 12082567

2002