Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 GeneticVariation LHGDN Variants in DISC1 affect the level of social anhedonia, a cardinal symptom of schizophrenia in the general population. 19188535

2009

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 GeneticVariation LHGDN We sought to detect rearrangements affecting DISC 1 in 347 individuals meeting the DSM3R criteria for schizophrenia or schizoaffective disorder, 70 subjects with bipolar disorder and 377 psychiatrically healthy controls, but failed to detect any pathological rearrangement. 18395819

2009

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 GeneticVariation LHGDN These findings implicate DISC1 in variation of prefrontal cortical volume and positive symptoms, thus providing a potential mechanism through which DISC1 may confer increased risk for schizophrenia or schizoaffective disorder. 18078707

2008

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker LHGDN To show that pericentriolar material 1 protein (PCM1) forms a complex at the centrosome with disrupted-in-schizophrenia 1 (DISC1) and Bardet-Biedl syndrome 4 protein (BBS4), which provides a crucial pathway for cortical development associated with the pathology of SZ. 18762586

2008

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 GeneticVariation LHGDN Moreover, they support the hypothesis that genetic variation in DISC1 may affect the risk for schizophrenia by modifying hippocampal gray matter and function. 19046394

2008

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker LHGDN Secondary analyses revealed no direct relationship between NDE1 genotype and SZ; however, there was an opposite pattern of risk for NDE1 genotype when conditioned on DISC1 Ser704Cys, with NDE1 rs3784859 imparting a significant effect but only in the context of a Cys-carrying background. 18469341

2008

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 GeneticVariation LHGDN We conclude that ultra-rare structural variants in DISC1 are associated with an attributable risk of about 2% for schizophrenia. 18164685

2008

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker LHGDN Our results suggest that DISC1 may be a susceptibility gene for poor concentration among Korean patients with SCZ. 17997036

2008

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker LHGDN Emerging genetic and biological data strongly supports Disrupted in Schizophrenia 1 (DISC1) as a schizophrenia risk gene of great significance for not only understanding the underlying causes of schizophrenia and related disorders but potentially to open up new avenues of treatment. 18497105

2008

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker LHGDN Disrupted-in-Schizophrenia-1 (DISC1) is now an important candidate risk gene for schizophrenia and affective disorders. 18474207

2008

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker LHGDN Among 3 genes associated with schizophrenia or bipolar disorder in multiple previous studies, including dysbindin (DTNBP1), neuregulin (NRG1), and disrupted-in-schizophrenia 1 (DISC1), only DISC1 showed evidence of association in this cohort. 18180429

2008

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker LHGDN Our findings provide further evidence for DISC1 as a predisposing gene involved in schizophrenia in the Chinese Han Population. 17286247

2007

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker LHGDN Altered DISC1-PDE4B interaction may thus underlie the symptoms of some cases of schizophrenia and depression. 17823207

2007

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 GeneticVariation LHGDN This analysis further strengthens the candidacy of DISC1 as a risk factor for schizophrenia in the general population, and suggests that more intensive searching for causative variants is justified. 16389590

2006

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker LHGDN The association of the DISC1 gene with schizophrenia was mainly in the patient group with sustained attention deficits as assessed by the Continuous Performance Test. 16997000

2006

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker LHGDN Evidence that a DISC1 frame-shift deletion associated with psychosis in a single family may not be a pathogenic mutation. 16936759

2006

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 GeneticVariation LHGDN Based on the genetic and functional evidence that DISC1 may be associated with schizophrenia, we sequenced portions of DISC1 in 28 unrelated probands with schizophrenia and six unrelated probands with schizoaffective disorder, ascertained as part of a large sibpair study. 15940305

2005

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker LHGDN This finding should stimulate studies aiming at the molecular characterization of how the specific alleles of DISC1 affect the visual memory functions and eventually participates in the development of schizophrenia. 16103888

2005

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 GeneticVariation LHGDN These convergent data suggest that allelic variation within DISC1, either at Ser704Cys or haplotypes monitored by it, increases the risk for schizophrenia and that the mechanism of this effect involves structural and functional alterations in the hippocampal formation. 15939883

2005

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker LHGDN These data suggest that DISC1 is associated with neurocognitive functioning in schizophrenia. 16056147

2005

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker LHGDN This result provides further supporting evidence for DISC1 as a susceptibility factor for both bipolar disorder and schizophrenia, consistent with the diagnoses in the original Scottish translocation family. 15838535

2005

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 GeneticVariation LHGDN The gene named DISC1, disrupted at the chromosome 1 breakpoint, is a novel candidate gene that may have a role in the pathogenesis of schizophrenia. 15184103

2004

Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.600 Biomarker LHGDN In this study we genotyped 28 single nucleotide polymorphisms (SNPs) from 1q42 covering the three candidate genes TRAX, DISC1 and DISC2, using a study sample of 458 Finnish families ascertained for schizophrenia. 14532331

2003