Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker LHGDN The neuregulin 1 promoter polymorphism rs6994992 is not associated with chronic schizophrenia or neurocognition. 18286587

2008

Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker LHGDN Our results suggest that there is an interaction between the IL-1B and NRG-1 genes in schizophrenia. 17901998

2008

Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Thus, our results suggest the possibility that interaction between variants in NRG1 and ERBB4 might contribute to susceptibility for schizophrenia in a Japanese population. 18704261

2008

Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Common risk genes for affective and schizophrenic psychoses. 18516516

2008

Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Rodents with NRG1 knock-out showed significantly impaired prepulse inhibition (PPI) in the original report linking NRG1 to schizophrenia. 17631867

2008

Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 AlteredExpression LHGDN We wished to investigate further the involvement of NRG1 in schizophrenia and bipolar disorder. 18466881

2008

Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker LHGDN The NRG1 status of 523 healthy subjects was determined with a single nucleotide polymorphism (SNP8NRG221533) which has been described as a tagging marker being part of the core at-risk haplotype for schizophrenia. 18455369

2008

Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 AlteredExpression LHGDN It is possible to select Nrg-1 mRNA expression of PBLs in schizophrenia patients as a potential therapeutic marker. 18455303

2008

Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 AlteredExpression LHGDN NRG1, ERBB3, and NGFR show expression changes during the years of greatest risk for the development of schizophrenia. 18470533

2008

Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN We hypothesise that variation in NRG1 may convey risk for schizophrenia by disrupting neural connectivity, possibly white matter integrity, and leading to a slower speed of cognitive processing. 18571900

2008

Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Together, these results suggest that the molecular mechanism of the association between NRG1 risk alleles and schizophrenia may include down-regulation of nAChR alpha7 expression. 17884806

2007

Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker LHGDN Since the initial report of association between neuregulin 1 (NRG1) and schizophrenia in 2002, numerous independent replications have been reported. 17033632

2007

Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker LHGDN At least two different haplotypes of the NRG-1 gene may be associated with schizophrenia. 17405926

2007

Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker LHGDN In this first study to select markers systematically on the basis of linkage disequilibrium across the entire NRG1 gene, we used haplotype-tagging single-nucleotide polymorphisms to identify single markers and haplotypes associated with schizophrenia and bipolar disorder in an independently ascertained Scottish population. 16940976

2007

Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker LHGDN Using a B lymphoblast cell model, we previously demonstrated impairment in NRG1alpha-mediated migration in cells derived from patients with schizophrenia as well as effects of risk alleles in NRG1 and catechol-O-methyltransferase (COMT), a second gene implicated both in schizophrenia susceptibility and in cancer. 18159252

2007

Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Our data suggest that type IV is a unique brain-specific NRG1 that is differentially expressed and processed during early development, is translated, and its expression regulated by a schizophrenia risk-associated functional promoter or single nucleotide polymorphism (SNP). 17565985

2007

Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 AlteredExpression LHGDN The DTNBP1 and, less so, NRG1 and DAAO variants might exert gene-specific modulating effects on schizophrenia endophenotypes at the population level. 17336946

2007

Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 AlteredExpression LHGDN We review the structure and functions of NRG1, consider the evidence for and against it being a schizophrenia susceptibility gene, and discuss mechanisms that might underlie the contribution of NRG1 to disease pathophysiology. 16442083

2006

Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN This meta-analysis supports the involvement of NRG1 in the pathogenesis of schizophrenia, but with association between two different but adjacent haplotypes blocks in the Caucasian and Asian populations. 16687441

2006

Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN We report the finding of a missense mutation in the neuregulin 1 gene associated with schizophrenia. 16730337

2006

Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Here we investigate the effects of a variant in the human NRG1 promoter region in subjects at high risk of schizophrenia. 17072305

2006

Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker LHGDN NRG1-induced suppression of NMDA receptor activation was more pronounced in schizophrenia subjects than in controls, consistent with enhanced NRG1-erbB4 signaling seen in this illness. 16767099

2006

Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Although the samples size is relatively small, the findings support a role for NRG1 in SZ in African Americans and suggest that polymorphic differences in regions of the gene that recognize AT-binding proteins may be a factor in disease pathogenesis. 16287046

2006

Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Our data require independent replication, but tentatively suggest that NRG1 may mediate its effects on schizophrenia susceptibility through functional interaction with erbB4, and that genetic interaction between variants at the two loci increases susceptibility to schizophrenia. 16249994

2006

Entrez Id: 3084
Gene Symbol: NRG1
NRG1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker LHGDN Our data support the hypothesis that NRG1 gene is a susceptibility gene for schizophrenia. 16326006

2006