Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN MTHFR 677C -- > T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val -- > Met. 18988738

2008

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Increased MTHFR 677T allele load confers risk for negative symptoms in schizophrenia, while reducing severity of positive symptoms. 17543893

2008

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN The MTHFR 677TT genotype showed a nearly significant increased risk for schizophrenia 17716874

2008

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN When combined with previous studies in meta-analyses there is still evidence for association between the MTHFR C677T polymorphism and schizophrenia. 18165967

2008

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN MTHFR C677T genotype contributes to certain executive function deficits in schizophrenia 17344026

2007

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN This meta-analysis suggests an association between the MTHFR C677T variant and the risk of developing depression, schizophrenia, and bipolar disorder/researchers found no such associations with the A1298C variant. 17074966

2007

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN This finding indicates possible association of BD and schizophrenia with the 1p36.3 MTHFR locus. 16545905

2006

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN The elevated risk of schizophrenia associated with the homozygous genotype of the MTHFR 677C > T polymorphism provides support for causality between a disturbed homocysteine metabolism and risk of schizophrenia. 16172608

2006

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene with schizophrenia: association is significant in men but not in women. 16084002

2006

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN A minor role for polymorphism of this enzyme in the pathogenesis of schizophrenia and depression cannnot be ruled out and would warrant further investigation. 15564899

2005

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Results exclude a major role for both C66T and A1298C variants of the MTHFR gene in conferring susceptibility to schizophrenia in two racially distinct populations. 15289817

2004