Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 GeneticVariation LHGDN Our results confirm that TNFalpha A allele could have an effect on vulnerability to schizophrenia but further studies revaluating the role of gender and diagnostic subtypes are necessary to confirm these findings. 17234379

2007

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 GeneticVariation LHGDN Our previous studies of genetic causes in schizophrenia supported findings of linkage to the major histocompatibility complex (MHC) region where the TNFalpha gene is located as well as association with the -G308A promoter polymorphism. 17171665

2007

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 GeneticVariation LHGDN Stratifying the 22 families with genome scan data by TNFA promoter haplotypes followed by reanalysis of linkage to schizophrenia throughout the genome, we identified few loci that exhibit a considerable increase in LOD/HLOD scores. 15340354

2005

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 GeneticVariation LHGDN Tumour necrosis factor alpha polymorphism (-1031T/C) is associated with age of onset of schizophrenia. 16027740

2005

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 Biomarker LHGDN However, TNF-alpha --G308A G/G homozygosity was modestly associated with schizophrenia in male patients. 15927374

2005

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 GeneticVariation LHGDN We conclude that the effect of the -308G > A polymorphism on the development of schizophrenia is, if any, weak and the majority of Japanese schizophrenics are unrelated to the -308G > A polymorphism of the TNF-alpha gene. 14767724

2004

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 GeneticVariation LHGDN The results of these investigations suggest that the TNF-alpha gene -308G/A variants do not play a major role in susceptibility to, clinical manifestations for, or clozapine response in, schizophrenia. 14623371

2003

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.400 GeneticVariation LHGDN Our data suggests association of the common G allele of the -G308A TNFalpha gene polymorphism with schizophrenia in a sample of 207 families. 14623370

2003